SPLENIC RUPTURE
SPLENIC RUPTURE, INCLUDING FATAL CASES, HAS BEEN REPORTED FOLLOWING THE ADMINISTRATION OF NEUPOGEN. INDIVIDUALS RECEIVING NEUPOGEN WHO REPORT LEFT UPPER ABDOMINAL AND/OR SHOULDER TIP PAIN SHOULD BE EVALUATED FOR AN ENLARGED SPLEEN OR SPLENIC RUPTURE."
http://www.neupogen.com/pi.html#warnings
" My WBC actually dropped back to 1.2 and this is with me on Neupogen.
Thanks for your reply. Its now march 4 th. All seems fine. I feel good again and not so week.
I guess neulasta's route of elimination keeps it's action (like neupogen) around much longer so that there probably would not be a reason for neupogen at that point.
Neupogen should be administered no earlier than 24 hours after the administration of cytotoxic chemotherapy. Neupogen should not be administered in the period 24 hours before the administration of chemotherapy. Neupogen should be administered daily for up to 2 weeks‚ until the ANC has reached 10‚000/mm3 following the expected chemotherapy-induced neutrophil nadir.
I take 1/2 dose of Neupogen on Mon, Wed. and Sat. I inject the Pegasus
on Friday. I was given the option of taking the Neupogen on Friday, to avoid 4 days of injections. I decided I rather do 4 days than 2 in one day.
Pegasus and Neupogen can be taken on the same day.
My doctor has assured me I can just about take it anytime without concern
for tx. I trust his opinion in that he treats medical professionals from around the country.
Because of the potential sensitivity of rapidly dividing myeloid cells to cytotoxic chemotherapy‚ do not use NEUPOGEN® in the period 24 hours before through 24 hours after the administration of cytotoxic chemotherapy.
http://pi.amgen.com/united_states/neupogen/neupogen_pi_hcp_english.pdf
(see bottom of pg 13.
Neupogen should be administered no earlier than 24 hours after the administration of cytotoxic chemotherapy. Neupogen should not be administered in the period 24 hours before the administration of chemotherapy. Neupogen should be administered daily for up to 2 weeks‚ until the ANC has reached 10‚000/mm3 following the expected chemotherapy-induced neutrophil nadir.
The one thing I learned from both his old posts as well as OHs is how tricky the timing can be with Neupogen. I knew out the outset to be vigilant about the timing of my labs and the Neupogen dose. Even though this was only weeks ago I see I saved myself some time and discomfort since I knew what to ask and what to look for when I started this med.
Its toxicity depends on the route of administration, duration, exposure and dosage. The route of administration is the most important determinant of toxicity. I hope this helps.
The side effects of the neupogen were more pronounced when I did them after my first tx, just like you said. I think that all the various side effects of the treatment drugs masked the sx of the neup. Seems like I took 3 or 4 shots after I was done, just to boost the WBC. We do what we have to do, don't we.
Would this route of administration work similar to faster acting benzodiazepines such as Xanax or Ativan, or does it depend solely on having a steady amount of Klonopin in your bloodstream already?
I'm confused; why would a doctor prescribe Klonopin for anxiety attacks (i.e., take it as needed)?
My latest blood test showed my WBC at 1.16. My doctor's nurse called today and told me he wanted me to skip my next dose of Pegasys. My WBC has been low in the past, but has held steady. I am 1a, 47 weeks into Tx - clear at 18 weeks, with a drop from over 6 million to 200 in first 12 weeks. I have no trust for this GE - confronted him yesterday about his plan to have me stop treatment at 58 weeks instead of 72.
Neupogen is a very often used rescue drug to help raise whit blood cells. many doctors would do this when the ANC gets to 500 and some would let it fall to 300 or so.
often tho ,,it will drop and then stabilize or even rise some. Good idea to get the Neupogen at the ready just in case that doesn"t happen and it continues to drop.
as my doctor said, and it was either take Neupogen along with Pegasys and Ribavirin or stop treatment all together. I have been clear of the virus since 11/08, but have had a slew of issues that are hindering my life. I was just wondering what others who took Neupogen experienced post treatment, if anything.
Thanks in advance!!!
I recall that when I started the neulasta (pegylated form of neupogen that stays in system longer), I was required to come back next day for blood draws to see if I responded to it and how well I responded. Towards the end of TX, the effects (holding my neuts above danger level) lasted a shorter time, so I guess the blood helper drugs may get less effective but they did still work.
The neupogen (or neulasta) works overnight. Other posters (was it nygirl?
Once I had to reduce to 1/2 of Riba because my ANC dropped to 400 and wouldn't come back up. I only did it for a week. I believe it's your ANC that is the driver not only your WBC. But, I know my dr. looked at my platlets & hemoglobin along with the ANC, before determining the reduction. When my WBC was around 1.8 - 1.9, I stayed on full tx.
I just read that a lot of people try NOT to take Neupogen unless it is a necessity due to sx. I am on Neupogen and I take it 3 times a week and have been taking it for 8 mos. now.
Does anyone know exactly why people/anyone would want to NOT take Neupogen?
Your answers may provide some insight for me and my sx's.
Recommended
