Believe it or not it is a common misconception that the naloxone in suboxone is what puts you into precipitated withdrawal. It is actually the Buprenorphine which is the active ingredient in both suboxone and subutex. The naloxone is in suboxone to prevent it from being injected. Injected the naloxone will make someone ill. Since sub is taken sublingually the naloxone takes no effect, it is not absorbed well via that method.
Suboxone contains a combination of buprenorphine and naloxone. Buprenorphine is an opioid medication. Buprenorphine is similar to other opioids such as morphine, codeine, and heroin however, it produces less euphoric ("high") effects and therefore may be easier to stop taking.
Naloxone blocks the effects of opioids such as morphine, codeine, and heroin.
Naloxone is a μ-opioid receptor competitive antagonist, and its rapid blockade of those receptors often produces rapid onset of withdrawal symptoms. Naloxone also has an antagonist action, though with a lower affinity, at κ- and δ-opioid receptors.
Actually this does make sense, it has to be inert because then the bupe would cause withdrawal, the bupe is a partial opioid agonist. The whole point of the naloxone added is to discourage taking it intravenously which would precipitate immediate withdrawal.
After my baby I was in a lot of pain, and had to go on Vicodin, I was worried there would be a reaction or not work, but it worked just fine. I had built up a tolerance rather quickly after a week, But it did help some with my pain.
Subutex does not have naloxone in it it shouldn't throw u into withdrawal only suboxone because of the naloxone rips the opiates out of ur brain n there's ur withdrawal
It is the Buprenorphine that causes precipitated withdrawal. Naloxone is not absorbed well under the tongue and is used to keep addicts from injecting sub.
This is from wiki....
http://en.wikipedia.org/wiki/Buprenorphine
Buprenorphine itself is mixed agonist/antagonist, and, as such, buprenorphine blocks the activity of other opiates and induces withdrawal in opiate dependent individuals who are currently physically dependent on another opiate.
and when they crush it and inject it...they will never do it again...it will activate the naloxone in it and make them soooo sick...
QUOTE:
"The naloxone in SUBOXONE is there to discourage people from dissolving the tablet and injecting it. When SUBOXONE is placed under the tongue, as directed, very little naloxone reaches the bloodstream, so what the patient feels are the effects of the buprenorphine.
What did your doctor say? How long did he tell you to wait before taking it?
Suboxone is typically used for addiction, and contains naloxone. You MUST be in moderate withdrawal before using it, scoring I believe a 26 on the scale before taking any of it. Otherwise you can be thrown into Precipatated withdrawal .
I would suggest discussing this with your PM doctor before considering this option.
Some have gotten relief, most have not.
I have to make a rare correction, Eagle-- Suboxone has naloxone, the IV form of naltrexone. I'm sure you have the principals down though-- naloxone is completely irrelevant to the action of Suboxone, and is there for show more than anything-- it does nothing to contribute to the actions of the drug, but is used to deter people from injecting Suboxone, since then the naloxone would be active.
Eagle is correct, Cathy-- buprenorphine, Suboxone, and Subutex are all essentially identical.
Because Naloxone can sometimes cause symptoms of opiate withdrawal, pregnant women wanting to take buprenorphine are normally advised to take Subutex instead. Subutex is exactly the same as Suboxone, but it contains no Naloxone, only buprenorphine.
If a women becomes unexpectedly pregnant while taking Suboxone – her doctor will probably recommend that she switch to Subutex, but not switch to methadone or any other form of treatment.
The Subutex formula was created for Patients with a known or suspected hypersensitivity to Naloxone (In some patients, Naloxone can cause excrutiating headaches), And women who are pregnant. In some clinics, Subutex is used as the Induction drug, and then switched to Suboxone for maintenance purposes. Utilizing monotherapy with Subutex, the physician can better pinpoint any reactions during induction.
How far along are you? Be very careful tapering down. If you stop the medication the baby could go in withdrawal in the womb and you could go into pre-term labor. I was told this by the pediatrician in NICU. My baby is in NICU now for withdrawal of Subutex I took during my pregnancy. They give him morphine and are taking very good care of him.
t prescribe subutex because it can be abused - the naloxone in the suboxone will cause immediate withdrawal if crushed and injected. Talk to a sub doc and depending on your circumstances, they may be willing to prescribe it over suboxone. However, if you are having a reaction to the buprenorphine, then you will have the same reaction with subutex.
If the pill is crushed and snorted or injected, the naloxone is activated and the patient will go into precipated withdrawal. No amount of additional narcotics will stop the withdrawal symptoms until the naloxone has worn off.
The idea behind using Subutex, Suboxone, and methadone for addiction therapy is to stabilize the patient, get him off the drug of choice and out of the cycle of chasing after a high and the assorted harmful behaviors that go along with addiction.
If there is a substitute a Dr will not give a woman Suboxone when they could take Subutex and not have to ingest the naloxone .Naloxone can cause a pregnant woman to not produce the necessary hormones needed for the pregnancy.
You have every right to be worried about the baby because she is lying. I guarantee her Dr's no nothing of the suboxone..Because if the OB is educated he would switch her to subutex. Her story is very fishy.
Good Luck.
instead of getting high, you can even go into precipitated, acute withdrawal as the naloxone displaces any current opiates sitting on receptors and prevents the buprenorphine from binding anywhere. Basically, the naloxone prevents 'abuse' - which means that *even if* a person wanted to try and get high from the contained partial-opiate buprenorphine, the results are either no reward or acute withdrawal.
The draw-backs:
Suboxone has a very long half-life.
Is he serious?? I’m not a guinea pig, I need to continue to work to support my family.. the withdrawal I went they from methadone was HORRIBLE.. never again.
I’m just curious tho? How bad is withdrawals from suboxone? Have u heard of Belcuca?
Zubsolv comes in sublingual tablet sizes of 5.7-mg/1.4-mg (buprenorphine/naloxone), and 1.4-mg/0.
Regarding injecting the Sub, check with his prescribing doctor about that. It's my understanding that the naloxone included in Suboxone is there for the exact reason of making injecting a very unpleasant experience - called precipitated withdrawal. Since you didn't notice withdrawal symptoms, my guess is that he tried to shoot heroin while on the Sub. Adding more opiates while on Sub doesn't result in the same reaction.
Buprenorphine has a much higher binding affinity for the mu(opiate) receptor than naloxone. A person who has been on Suboxone can shoot/snort as much as they want and the naloxone will have no effect at all because of that. Hell you can read that on Wikipedia of all places. The reason the pharm company (RB) put naloxone in Subs was to lengthen their patent on it. Notice there are generics for Subutex but no generics for Suboxone???? Oh and then RB put out the Suboxone film strips....
This means that it is not known whether buprenorphine and naloxone will be harmful to an unborn baby. Use of buprenorphine and naloxone during pregnancy may cause withdrawal symptoms in a newborn baby. Do not take buprenorphine and naloxone if you are pregnant or could become pregnant during treatment.
Contrary to what you may have heard methadone is not safe during pregnancy, it is actually more dangerous to a baby than heroin. I am not sure why doctors prescribe it but they shouldn't.
Hi Tiger,
I am also on 16 mg of suboxone a day. Once I waited maybe 12 hours and took roxicet. It's 30 mg of oxycodone. I had to take 7 of them to feel any kind of relief and I don't have any documented pain problems. I don't know if you ever heard of rivea. If you take any opiates with that, like you said, you could have withdrawals and I was told if I took a painkiller, it wouldn't work. So, I guess the longer you wait since taking sub, the better the MS Contin will work.
Recommended
