Moxifloxacin and ngu
Common Questions and Answers about Moxifloxacin and ngu
avelox
Although primarily a respiratory infection, some types of adenovirus infect the urethra, probably through oral sex, and adenovirus causes 2-3% of cases of nongonococcal urethritis (NGU). And adenovirus typically causes conjunctivitis as well -- and there have been published cases of sexually acquired NGU along with conjunctivitis.
http://www.cdc.gov/std/treatment/2010/urethritis-and-cervicitis.
Be that as it may, with repeated treatments with both doxycycline and azithromycin, you may wish to talk to your doctor about a course of moxifloxacin. Your situation is a difficult one and moxifloxacin has proven to be effective against chlamydia, mycoplasma genitalium and gets into the prostate well.
Hope this helps.
Welcome to the forum. Thanks for your question.
First, so there is no confusion on terminology: nongonoccal urethritis (NGU) and nonspecific urethritis (NSU) are the same thing. NGU is the usual term in North America (and the one I will use in my reply), NSU in the UK and many commonwealth nations.
Second, your symptoms are somewhat more suggestive of gonorrhea than NGU, especially during the second episode 3 weeks later ("strong yellow discharge").
A couple weeks later, my urethritis and drip gets even worse and I start to have full on discharges.I get tested yet again, and I bring girl #1 with me. She's had absolutely no symptoms. She was even examined and the doctor said she looked fine.We both get Doxycycline and I feel better.Tests were negative.I then continued to have unprotected sex with girl #1 and everything is normal.A couple months later I start having sex with girl #2 again.
And by the way, the 40% azithromycin failure rate is only for NGU caused by M gen, which in turn is the cause of only 10% of NGU. And your symptoms cleared nicely on azithro, which itself is strong evidence that you were cured.
I would not recommend further treatment with moxifloxacin or anything else.
Clinicians are testing out of protocol out of sheer ignorance and then sending off people with no answers, or worse yet, putting people on 30-60 days of cirpofloxacin and levofloxacin which has no effective cure against MG and only makes Moxifloxacin useless because MG gains resistance from cipro/Levo.
Moxifloxacin is still a hope for 70% of the cases. For many due to prior treatment of a flouroquinolone its useless.
You options are test full ejaculate and FVU together.
In the meantime, i took azrithromyocin 1gm, next day, flagyl, then a 2 week dose of doxycycline and one cipro pill. My doc wanted to cover all my bases in case it was an NGU. I still have the mild irritation and rarely have mild relief at times. No pain with urination or palpation. Had prostate checked for prostatitis, no uti either. My question is, what is it?? Can it possibly be some kind of yeast? Seems like i have been tested for all else with urinalysis and blood tests.
genitalium as a potential cause of NGU and the fact that moxifloxacin is a reliable treatment and therefore has a role in some cases of NGU that persists after azithromycin or doxycycline. The new guidelines were formally released only 2 weeks ago, so it's not entirely surprising they are unfamiliar.
In any case, M. genitalium is not the most likely problem here. Urine culture and senstivity implies testing for a non-STD UTI, which is unlikely.
Also i have a slight irritation from time to time in urethra. i will be willing to travel for a test and answers. I'm assuming planned p will test for usual stds and say I'm fine don't worry.
so ive done a bit of digging and found this information with regards to NGU/NSU from user "HowardH"
CDC treatment guidelines suggest a specific sequence for NGU that doesn't respond to treatment: Initial NGU should be treated with either azithromycin (single dose) or doxycycline 7 days; if it persists (by professional exam, not just symptoms), give the alternat drug, i.e.
Your doctor apparently is quite knowledgeable about STDs, since he knew to prescribe moxifloxacin -- which is the CDC recommendation for NGU that persists after both doxy and azithromycin. The chance it will cause significant toxicity is quite low.
Continue to follow your doctor's advice on this. There's not much more I can do here.
Okay, sorry. It helps me if all of your questions are in one place so I can have all the info together.
I do think that you should be checked for NGU, if for no other reason than to make sure you're all clear. NGU is a risk from receiving oral, and while the discharge you are seeing may be normal, or may be from you checking so often, you should rule it out.
You could also stop checking for a few days, see if you see any more symptoms, and then make a testing decision based on that.
You had an accurate reply in a previous thread. M genitalium is not known to be transmitted by oral sex.
The "scientific literature" you quote undoubtedly is more reliable than non-scientific sources of information, and I doubt there are any scientifically reliable sites -- government (e.g. CDC or otherwise) -- that say M genitalium can be acquired by oral sex. Dr. Handsfield's statement looks accurate to me. Nobody tries to "scare people into practising safe sex".
If you meant to say that you took Moxifloxacin, and you still have symptoms, it just means that you have multi drug resistance MG. Yes, there are STD’s in this country that are not known about AND MG is the culprit behind many undiagnosable urethritis/prostatitis issues.
This is way more common than the doctors even know about. I’m not saying this to scare you, I’m saying this. because it’s the truth.
doxycycline, azithromycin and moxifloxacin. The first two failed to clear my infection and now I have two days that I finished the moxifloxacin 400 mg( 10 days treatment) clearing my symptoms. My question is, Is it possible for the bacteria to reoccur after the moxifloxacin treatment? And if yes what other option are there?
I was then treated with moxifloxacin (moxifloxacin 400 mg qd x 7) and cefixime (400 mg x 1). The previously mentioned symptoms persisted, as did intermittent aching in the groin and testicles. I also began experiencing some intermittent joint pain in hands and feet as well on the soles of my feet and my heel; occasionally, also redness and watering of the eyes.
Some cases may be inflammation without infection. Also, there is overlap between NGU and prostatitis -- and this may still be primarily a prostate problem, entirely unrelated to STD.
Your doctors are following the standard approach, i.e. re-treat with doxycycline, especially some time has passed since your previous episode (e.g. several weeks or more).
unfortunately though i had unprotected oral sex (she had almost degenerated coldsore, gray appearance crust under her lip) after 1 week and half of that night i developed painful urination, itchy and tingling sensation at the tip of my urethra, i ran to urologist, he said it's probably NGU, because he haven't seen signs of herpes which are blisters on penis, he also didn't see discharge from penis, he then sent me to er to check if i had prostate infection but it came out negative,
Neither recurrent NGU nor NGU acquired by oral sex is known to cause any harm to sex partners, and treatment of infected persons' partners is not known to have any benefit for their health. It is routinely done as a precaution, but nobody knows whether it really is necessary. In any case, after the treatments you have had, you can safely assume that any infectious agent initially present now is gone.
A recent study was done to show that Myco was only erradicated by 85% of those on the Azithro regiment described, however Avelox ( Moxifloxacin) killed Myco in all cases. Routine is to try described Azithro regimen first and if symtoms still exist Moxifloxacin. Why? I guess so that Myco doesn't become Moxifloxacin resistant. Save the bugs, kill the patient kind of thing. I say take the 400mg a day X 10 day regiment of Moxifloxacin and help yourself.
In your first response to me, you mentioned something about a recurrence of NGU. The question then is, if NGU is a bacterial infection, which I think it is, and it is appropriately treated with azithromycin and ciprofloxacin, how does it recur without a subsequent re-exposure to the bacteria?
Second, also based on what you have said in other threads, NGU does not pose significant health risks to female partners. Do I have that right?
recurrent/persistent NGU, chronic prostatitis, and CPPS all are only inconveniences, not serious health problems. Almost certainly you have nothing that will seriously harm you or a future sex partner. It is possible you will have to learn to live with your symptoms, but if they are not severe that should be pretty easy once you are confident you have nothing serious.
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