Metolazone hyponatremia
Common Questions and Answers about Metolazone hyponatremia
skelaxin
I have a question regarding the diuretic Metolazone. As background, my father is quite elderly at 85, suffering for the last five years from congestive heart failure (CHF) following two heart attacks 10 years ago. His condition has been treated successfully to date by use of lasix diuretic.
Two weeks ago, he gained water weight, and lasix did not work. The doctor prescribed Metolazone, a more powerful diuretic. This removed water, but from about 2 days after he started Metolazone, he began a downward spiral. He developed a potassium shortage, treated by a supplement. Metolazone was stopped, but he has become too weak to walk, and his thoughts are clouded. His water weight is normal.
"We also asked if he had any other patients showing similar symptoms after taking Gleevec but got no response. "
Well, from the cited article "Electrolyte Disorders Induced by Antineoplastic Drugs", we have:
"In cancer patients, hyponatremia has an overall prevalence up to 47% with mild, moderate and severe degrees accounting for 36, 10, and 1%"
So while severe is rare, overall is not at all rare.
The GP contacted the heart failure Specialist who advised increasing spironolactone to 50 mg and if weight still increased he could take a metolazone every 2 nd day if necessary . Ihave worked out that if he has some salted peanuts small amount that the cramps are much reduced . But thank you both for your advice it is much appreciated.
Hyponatremia is a common electrolyte disorder defined as a serum sodium level of less than 135 mEq per L. Treatment is based on symptoms and underlying causes. In general, hyponatremia is treated with fluid restriction (in the setting of euvolemia), isotonic saline (in hypovolemia), and diuresis (in hypervolemia).
For more information, see Figure 1 and Table 1 in the following article:
https://www.aafp.org/afp/2015/0301/p299.
If you have hyponatremia maybe. Did they do a blood test? How long did they say to eat more then average sodium?
What would be a rough formula for calculating sodium excretion. This has to handle extreme results like acute hyponatremia and hypernatremia.
What is the maximum excretion at which point the body is unable to keep up with consumption?
This information will not be used for any actual medical purpose on any actual organism, inaccuracy is acceptable and even intended to keep the calculations simple.
He went to the doctor last week and they increased his lasix - 160 mg twice a day. No change to the edema. He went back yesterday and they prescribed Metolazone (diuretic). He took one this morning at 7:00 am and at 10:00 am he had not noticed any increase in urination. He also went to his cardiologist yesterday who said he did have fluid around his heart (cause of the coughing) but agreed with the diuretic prescription.
Then was given Cefuroxime, Linezolid antibiotic, corex syp and metolazone diuretics when partially conscious. He didnt eat much drank 50 ml water in last 14 hours and nothing after that. Later in the evening his oxygen was down to 70 SpO2. In 1.5 hours he was given oxygen with oxygen machine and the oxygen started to increase in a bit. In an hour heartrate started to fluctuate BP was almost NR. The patient suffered cardiac arrest few minutes later. The patient wasn't a major heart patient.
Hi,
Drinking too much water can lead to a condition known as water intoxication and to hyponatremia. This is most commonly seen in infants under six months of age and sometimes in athletes. This also results when a dehydrated person drinks too much water without the accompanying electrolytes.
Excess water outside the cells draws sodium from within the cells out to re-establish the necessary concentration. As more water accumulates, the serum sodium concentration drops , hence, hyponatremia.
On August 23rd, 2014, he was diagnosed with Tonsillitis, Hypertension, Hyponatremia, Hypokalemia and Hypoxemia by one hospital.
Check for hyponatremia, it sounds like potential symptoms of hypoadrenalism. Do you crave sodium at all?
Then she got ill and stopped when she was admitted to the hospital for low sodium/high potassium levels and was given an IV, I believe at that time they said it was hyponatremia. She is currently taking gabapentin with no real affect. Her condition has not improved but has gotten various diagnosis from Fribromyalia to Issacs Syndrome.
Can you shed some light on this?
Thanks!
Hi,
Water is almost 60 percent of our body weight. Aside from the kidneys, where in it flushes toxins out of vital organs, it also helps carry nutrients to the cells and provides a moist environment for ear, nose and throat tissues. We may need to modify our total fluid intake depending on how active we are, the climate we live in, our health status, and if pregnant or breast-feeding.
It is possible to drink too much water.
Drinking too much water can lead to a condition known as water intoxication and to a related problem resulting from the dilution of sodium in the body, hyponatremia. Water intoxication is most commonly seen in infants under six months of age and sometimes in athletes. A baby can get water intoxication as a result of drinking several bottles of water a day or from drinking infant formula that has been diluted too much. Athletes can also suffer from water intoxication.
Muscle cramps can be very disturbing and can occur in many situations, like rest or nocturnal cramps, fatigue cramps, hyponatremia, hypocalcemia or tetany, hypomagnesemia, hypokalemia, contractures. Also inherited in MacArdle’s disease, protective reflex from injury, hypokalemia. Certain issues have been ruled out, get a fresh investigation done for the others. Considering her age group, muscular dystrophies also need contemplation. pseudo tumor cerebri is not associated with muscle cramps.
Hi there. You need to rule out electrolyte disturbances like hypocalcemia, hyponatremia, hypo and hyper kalemia, hypomagnesemia and hypoglycemia. metabolic conditions like hypothyroidism, hyperthyroidism related myopathy, drugs like salbutamol, alcohol consumption, amyotrophic lateral sclerosis, parenteral nutrition, hyperventilation etc.
org/wiki/Water_intoxication
Water intoxication, also known as water poisoning or dilutional hyponatremia, is a potentially fatal disturbance in brain functions that results when the normal balance of electrolytes in the body is pushed outside safe limits by over-hydration.
Water, just like any other substance, can be considered a poison when over-consumed in a specific period of time.
Some medications (tranquilizers, sleeping pills, antihistamines) and medical conditions (such as hypothyroidism, hypercalcemia, and hyponatremia /hypernatremia) may also be contributory. Diagnostic tests that may be performed include CT scan of the head, EEG, sleep studies and urine tests may also be done. Take care and regards.
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