During moderate/sever flare-ups I took prednisone orally, in foam suppository as well as mesalamine orally and through suppository. In moderate flare-ups mesalamine orally w/ mesalamine suppositories.
My question is - beyond the general risk that HSV presents - how additionally risky is this for me? It is a possibility that at some point I will have a flare-up that will require immonusuppressive therapy. If I was to contract HSV could my UC symptoms become more severe?
Her gastroenterologist started her on Mesalamine (4 capsules daily) and later added prednisone 100 mg enemas to try and get the flare-up under control. Things are getting better and she has some of her strength back. There is one puzzling thing that the doctors are not able to pinpoint. This is an intermittent fever that starts in the afternoon and lasts to the night. In the morning the temperature is back to a low 97 degrees fahrenheit and stays stable until afternoon below 98 degrees.
My recent result of biopsy after the colonoscopy indicates epithelial dysplasia. My doctor just advice me to continue taking the mesalamine (Asacol) Do i need an another urgent medication/treatment for dysplasia? What should be my next move?
I have read about a study in which Boswellia was used in conjunction with Mesalamine. My gastroenterologist knows notheing about herbs, but is open to information that I can give her. What is available? Are there any interactions with boswellia and mesalamine that I should be cautious about? Are there any precastions about its use?
Hi there,
I was diagnosed with sigmoidal colitis in 2005, but I reckon that it went unchecked for about 4 years prior to that. I was initially treated with mesalamine (Asacol) but it had no effect. My GI guy then hit me with prednisone and that knocked it down. I have been on Asacol in a prophylactic capacity since (800mg tid). Does it keep me in remission. Maybe, but maybe it is the tremendous quantities of fentanyl, diacetylmorphine and morphine I abused as well for all I know :P.
What other symptoms are present? Mesalamine or Canasa suppositories works by preventing the production of substances that cause the inflammation of the colon. The usual side effects include diarrhea; dizziness; gas; hair loss; headache; mild stomach discomfort or pain; and nausea. The sour taste could be indirectly related especially if you have other gastrointestinal issues like acid peptic disease or gerd.
Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs. Methadone has a typical elimination half-life of 15 to 60 hours with an average of i would say about 22. However, metabolism rates vary greatly between individuals, up to a factor of 100 ranging from as few as 4 hours to as many as 130 hours, or even 190 hours. So it's hard to say.
There have been a few cases of liver failure possibly related to the use of mesalamine (the active ingredient in Asacol HD), but I haven't read anything about fatty liver as a side effect.
A fatty liver, it takes between 6 months and 2 years to fully reverse. Dr Sandra Cabot's article "Fatty Liver - What Is Fatty Liver And How To Reverse It?
The water solubility of bilirubin allows the bilirubin to be excreted into bile. (Bile then is used to digest fats.)
Total bilirubin, if I remember correctly, is the conjugated hemoglobin, since there is also another portion that is not conjugated.
What the elevated total bilirubin means at this point is 'something' is going on, but you may need more information before your doc can determine the cause.
She again had colonoscopy and histological examination inferred that it was ulcer. She is being treated with Mesalamine and now she is well. Please check with your doctor.
The periods of remission can last from weeks to years."
***
Springer - Mimics of Ulcerative Colitis...
"Infectious colitides such as Clostridia difficile, hemorrhagic E. coli, Campylobacter, Aeromonas, and Salmonellosis can often present as severe ulcerative colitis. Other infectious pathogens, which also need to be included in the differential diagnoses, include Amebiasis, Shigellosis, Cytomegalovirus, and Rotavirus.
The main requirements for them are (1) high IFN-inducing activity, (2) absence of side effects, (3) wide spectrum of antimicrobial activity, (4) broad therapeutic security and, (5) good solubility in water and biologic liquids. IFN inducers stimulate IFN production in different cells and organs, and that determines the strategy for their application. Amixin (OOO "Lancepharm," Moscow, Russia) induces IFN-?/? production mostly in T cells. Cycloferon (NTFF "Polysan," St.
However, factors that can affect absorption include oral pH, salivary enzymes, lipid solubility, and molecular weight (molecules may be too large to pass through the mucous membranes). A sublingual product, specifically created to ensure effective absorption, is recommended.
I have Crohn's also. I'm pregnant with my second child and have not had a problem either time. However, my doctors did tell me that if you're Crohn's is under control when you get pregnant, it's likely that your condition will stay the same or get better during pregnancy. If you're having a flare up or the disease is not controlled well when you get pregnant it will likely get worse.
In terms of medication I would trust your doctors here.
If it is not effective, then other medications like steroids, mesalamine and bismuth subsalicylate may be tried.
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The information provided is for patients’ education only and is not a medical advice. Always consult your personal physician for complete evaluation of your health problem.
- Ratnakar Kini M.D.
Hi Nicky.
I'm sorry about your recent U.C. diagnosis.
According to the mfg:
"The dosage of Mesalamine 500 mg suppositories (Generic Canasa) is one rectal suppository once daily at bedtime.
The suppository should remain inserted for one to three hours or longer, if possible. The normal course of therapy is from three to six weeks depending on symptoms and sigmoidoscopic findings".
So the 30 day supply falls within the recommended duration.
(By the way, although losartan is currently being researched in Johns Hopkins clinical trials, other ARBs such as telmisartan are probably most effective given their increased lipid solubility and thus increased tissue penetration.)
I strongly encourage you to visit www.marfanlife.net and find the very lengthy thread titled "Losartan" or something to that effect. Probably some of the most important reading of your life.
07-2007 - to help fight off inflammation. I've read that prescription drugs were often safe, way beyond the expiration date. Don't have much of it left though.
So without going through the 'hassle' of getting an appointment, trying to get treatment, etc. is there something I can do on my own?
Thank you.
This all occurred after starting a 30 day course of Canasa (Mesalamine) to which I had rash and breathing problems in what seems to have been an allergic reaction and possibly triggered the above problems.
I am now on Claritin (10mg), Lexapro (5mg) and Aciphex which together brought relief to stomach pain within hours.
Cardiologist sees no Eosinophilic infiltration or Loeffler’s.
Repeated Endoscopies show no problems. I am negative for Eosinophilic Gastroenteritis.
the brain is affected quickly as alcohol will cross what is called the blood-brain barrier due to its solubility. this can compromise involuntary actions such as heartbeat, breathing and gag reflex. organs such as the liver and pancreas can suffer tissue destruction resulting in everything from lowered function and scarring to complete organ failure. for diagnosing existing damage, your doctor can order bloodwork including a liver panel to check things like enzyme levels.
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