Furthermore, the impairment of cell proliferation was demonstrated to be linked to induction of the inhibitory protein kinase A (PKA) pathway by HIV proteins. This induction of PKA was accompanied by an increase in intracellular cAMP, which is necessary for the activation of PKA. Finally, increases in cAMP/PKA activity were shown to induce biochemical changes that impaired proliferation when cells were stimulated with phytohemagglutinin.
During moderate/sever flare-ups I took prednisone orally, in foam suppository as well as mesalamine orally and through suppository. In moderate flare-ups mesalamine orally w/ mesalamine suppositories.
My question is - beyond the general risk that HSV presents - how additionally risky is this for me? It is a possibility that at some point I will have a flare-up that will require immonusuppressive therapy. If I was to contract HSV could my UC symptoms become more severe?
Her gastroenterologist started her on Mesalamine (4 capsules daily) and later added prednisone 100 mg enemas to try and get the flare-up under control. Things are getting better and she has some of her strength back. There is one puzzling thing that the doctors are not able to pinpoint. This is an intermittent fever that starts in the afternoon and lasts to the night. In the morning the temperature is back to a low 97 degrees fahrenheit and stays stable until afternoon below 98 degrees.
My recent result of biopsy after the colonoscopy indicates epithelial dysplasia. My doctor just advice me to continue taking the mesalamine (Asacol) Do i need an another urgent medication/treatment for dysplasia? What should be my next move?
Uric acid has 4 ionizable hydrogen ions (positions 1, 3, 7, and 9). Only the hydrogen ion on position 9 (pKa = 5.8) is ionizable at physiologic pH. Sodium urate is 15 times more soluble than uric acid. When pH equals pKa (5.8), uric acid and sodium urate are present in equal quantities. As pH increases, the ratio of sodium urate to uric acid increases. At a pH of 6.8, 10 times more sodium urate is present than uric acid; whereas, at a pH of 7.
I have read about a study in which Boswellia was used in conjunction with Mesalamine. My gastroenterologist knows notheing about herbs, but is open to information that I can give her. What is available? Are there any interactions with boswellia and mesalamine that I should be cautious about? Are there any precastions about its use?
Hi there,
I was diagnosed with sigmoidal colitis in 2005, but I reckon that it went unchecked for about 4 years prior to that. I was initially treated with mesalamine (Asacol) but it had no effect. My GI guy then hit me with prednisone and that knocked it down. I have been on Asacol in a prophylactic capacity since (800mg tid). Does it keep me in remission. Maybe, but maybe it is the tremendous quantities of fentanyl, diacetylmorphine and morphine I abused as well for all I know :P.
What other symptoms are present? Mesalamine or Canasa suppositories works by preventing the production of substances that cause the inflammation of the colon. The usual side effects include diarrhea; dizziness; gas; hair loss; headache; mild stomach discomfort or pain; and nausea. The sour taste could be indirectly related especially if you have other gastrointestinal issues like acid peptic disease or gerd.
There have been a few cases of liver failure possibly related to the use of mesalamine (the active ingredient in Asacol HD), but I haven't read anything about fatty liver as a side effect.
A fatty liver, it takes between 6 months and 2 years to fully reverse. Dr Sandra Cabot's article "Fatty Liver - What Is Fatty Liver And How To Reverse It?
She again had colonoscopy and histological examination inferred that it was ulcer. She is being treated with Mesalamine and now she is well. Please check with your doctor.
The periods of remission can last from weeks to years."
***
Springer - Mimics of Ulcerative Colitis...
"Infectious colitides such as Clostridia difficile, hemorrhagic E. coli, Campylobacter, Aeromonas, and Salmonellosis can often present as severe ulcerative colitis. Other infectious pathogens, which also need to be included in the differential diagnoses, include Amebiasis, Shigellosis, Cytomegalovirus, and Rotavirus.
I have Crohn's also. I'm pregnant with my second child and have not had a problem either time. However, my doctors did tell me that if you're Crohn's is under control when you get pregnant, it's likely that your condition will stay the same or get better during pregnancy. If you're having a flare up or the disease is not controlled well when you get pregnant it will likely get worse.
In terms of medication I would trust your doctors here.
If it is not effective, then other medications like steroids, mesalamine and bismuth subsalicylate may be tried.
================================================================
The information provided is for patients’ education only and is not a medical advice. Always consult your personal physician for complete evaluation of your health problem.
- Ratnakar Kini M.D.
Hi Nicky.
I'm sorry about your recent U.C. diagnosis.
According to the mfg:
"The dosage of Mesalamine 500 mg suppositories (Generic Canasa) is one rectal suppository once daily at bedtime.
The suppository should remain inserted for one to three hours or longer, if possible. The normal course of therapy is from three to six weeks depending on symptoms and sigmoidoscopic findings".
So the 30 day supply falls within the recommended duration.
07-2007 - to help fight off inflammation. I've read that prescription drugs were often safe, way beyond the expiration date. Don't have much of it left though.
So without going through the 'hassle' of getting an appointment, trying to get treatment, etc. is there something I can do on my own?
Thank you.
This all occurred after starting a 30 day course of Canasa (Mesalamine) to which I had rash and breathing problems in what seems to have been an allergic reaction and possibly triggered the above problems.
I am now on Claritin (10mg), Lexapro (5mg) and Aciphex which together brought relief to stomach pain within hours.
Cardiologist sees no Eosinophilic infiltration or Loeffler’s.
Repeated Endoscopies show no problems. I am negative for Eosinophilic Gastroenteritis.
the doctor at the time told me that it was the same thing as asacol, however, i found it to be less effective. another doctor later told me that they have the same active ingredient mesalamine, but pentasa reaches a different part of your track... i think asacol stays intact longer, so it gets released lower down in your system.
anyway, i think either of the 2 drugs are mainly for maintenance like the others said.
They are all different names for Mesalamine. So they should all be the same formula and work the same. I know from experience that sometime the brand works better than generics, but thought I would share this information with everyone.
Do you get cramping or spasms? Here is a list of meds. I have taken that has worked for me. Lialda(mesalamine)
Hyoscyamine(capsule,@sublingual)
Prednisone(works for me, but do not reccommend)
Protonix(gas @ bloating)
You should probably start keeping a food diary journal now.Thats how we try to find the foods that trigger our symptoms.
Why are carrots bad for UC? My 16 y/o son recently diagnosed with UC. He is on mesalamine and prednisone but keeps bleeding although stools are better. His diet at this point consists only of chicken, ground turkey, white rice, low fat tortillas and some cooked canned carrots and muscle milk drink plus water, gatorade and probiotics. He has a lot of severe food allergies which complicate diet. He is losing weight and he is an an athlete so this is disconcerting of course to him..
Recommended
