d say at least 6 hours after your morning
dose. You can reduce side effects by taking your
dose with food. I tried this and it is 100% true. I couldn't tolerate the drugs without food. According to Drugs.com however (havent read this anywhere else), taking Kaletra with food showed a 20% reduction of blood levels of the medication. Though they can be taken with or without food, I opted to take my morning dose with food, and my evening dose on an empty stomach.