imatinib resistance

Eithne01, The treatment of chronic myeloid leukemia (CML) has changed significantly since the late 1990s, with the development and subsequent approval by the Food and Drug Administration of imatinib (in 2001), the first of a class of medications called tyrosine kinase inhibitors, which target the specific abnormality that causes CML. Before that time, patients were treated with other therapy, including interferon and bone marrow transplant, and had very poor outcomes.

It is possible that the white blood cell count would normalize after 2 weeks of taking Imatinib (Gleevec). Most responses to Imatinib are rapid since it targets the molecular pathogenetic event in CML. You may seek a second opinion if that will give you a peace of mind. Good luck.

lots of people die all the time because they reject traditional treatments and go with 'natural' things instead I would think of using alternatives along with regular treatments, but not in place of them. Some alternative things might have some benefit. Isn't homeopathy the approach where you dilute some substance down to one part per billion or so, and then expect it to actually have some curing power?

Are you currently on any medication like imatinib? The neutropenia can be due to your current medication. You can ask your hematologist for G-CSF injection if you have persistent neutropenia. Patients with CML are immunocompromised and can easily acquire infections. Neutropenia also puts a patient in an immunocompromised state. For now, it is very important to prevent acquiring any infection. You should avoid crowded places and persons with ongoing infection. Good luck.

Hi. Chronic Myelogenous Leukemia (CML) is a blood disorder caused by an acquired genetic defect in the pleripotent stem cell. It has several phases: indolent chronic or stable phase, aggressive or advanced phase, and accelerated and blastic phase. The transition between phases may take years (on the average, 4 to 6 years from the stable phase to aggressive phase).

Average survival rates are generalizations, not applicable to a particular patient. The prognosis is relatively good. Newer techniques are being tried, including imatinib and stem cell transplantation. All the best, and God Bless!

You can develop resistance to a STAT-C drug however. So when someone is choosing a trial with a STAT-C drug involved, you want to choose with care - the same will apply when undergoing treatment with a STAT-C drug when they finally get to market. You want a doctor/treatment team who understands the issues and you'll want to understand them yourself so that your first attempt with a STAT-C drug is as hopefully your last.

TY for the reply. Yes I was told and am thinking that its parasitc or allergy. I went to aruba in June but that wouldn't have an affect on me now, would it?

IR or insulin resistance is a sign of type 2 diabetes or pre-diabetes. I am assuming you are referring to either the A1C or fasting blood glucose levels. The first thing of course is a change in life style. This does not mean you have to stop eating everything but to be more judicious in your eating habits. In addition, regular exercise is paramount in reducing those :numbers". Talk this over with your physician and get started on these changes.

There is little doubt that the indiscriminate use of antibiotics has contributed to the emergence of bacterial resistance, both in hospitals and community settings [1]. The major force driving changes in the prevalence of resistance in the community seems to be the volume of drug use [...]" http://cid.oxfordjournals.org/content/33/Supplement_3/S170.

there have been only one or two reported cas of true resistance of Chlamydia trachomatis to doxycycline and/or azithromycin. If it works out that way, I would expect your doctors to write up a scientific report for publication. I that event, I would not venture a guess about the best alternate treatment to use; that decision would rest on the lab tests to determine the best choice.n However, I still would not worry about eventual treatment success; there has never been a C.

Hi! I need some ideas on different resistance training I can do at home? Trying something new so any ideas are welcome! Thanks!

I have an appointment with my obgyn a week from Monday to follow up with him. Should I be tested for an immune deficiency or resistance? Any advice welcome.

On the report it did not show outside the normal but she said the usually accepted cut off for insulin resistance was lower than my level. I was placed on 500mg metformin, told to cut out process/refined sugar, carbs, and be re-tested. This process has continued and now I am on 2000 mg of metformin and my levels are actually higher. I have not been perfect with the diet but certainly much better than before.

Imatinib resistance

Common Questions and Answers about Imatinib resistance

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