Eithne01,
The treatment of chronic myeloid leukemia (CML) has changed significantly since the late 1990s, with the development and subsequent approval by the Food and Drug Administration of imatinib (in 2001), the first of a class of medications called tyrosine kinase inhibitors, which target the specific abnormality that causes CML.
Before that time, patients were treated with other therapy, including interferon and bone marrow transplant, and had very poor outcomes.
9 year old with history of Familial PAH in one parent has reported mild TR between 30-35 mm Hg and 35-37mm Hg respectively in 2 successive Echos over a period of 6 months.
The pediatric cardiologist wrote it down as "Mild PAH" with no changes in heart structure.
What precautions should one take to initiate lowering of pressures and/or prevent progression to PAH?
Thanks.
Are you currently on any medication like imatinib? The neutropenia can be due to your current medication. You can ask your hematologist for G-CSF injection if you have persistent neutropenia. Patients with CML are immunocompromised and can easily acquire infections. Neutropenia also puts a patient in an immunocompromised state.
For now, it is very important to prevent acquiring any infection. You should avoid crowded places and persons with ongoing infection.
Good luck.
PAH would be the result of pleural effusion. The most common causes of exudative pleural effusions are pneumonia, malignancy, pulmonary embolism (blood clots), etc.
The right side ventricle is pumping against higher than normal resistance, and the pressure is increased to overcome the resistance. Not properly treated the ventricle can increase in size to compensate for the higher resistance, and eventually overcompensate and a loss of contractility.
I have just been diagnosed with PAH, and chronic pulmonary heart failure. I am out of breath at rest, can hardly talk because of breathing problems, and have difficulty swallowing. I was wondering if anyone knows about how much time I have. Also, could my Ulcerative Colitis be a contributing factor? Thank you.
Hi.
Chronic Myelogenous Leukemia (CML) is a blood disorder caused by an acquired genetic defect in the pleripotent stem cell. It has several phases: indolent chronic or stable phase, aggressive or advanced phase, and accelerated and blastic phase. The transition between phases may take years (on the average, 4 to 6 years from the stable phase to aggressive phase).
The doctor stated that they have done everything that they could do. She has PAH, Lung diease, Heart failure and also a diabetic. She is in the hosipal right now and has been there for the last 2 1/2 wks. Her oxygen level falls low as 69. Can you tell me is her oxygen level every going to level out.
I have Systemic Sclerosis (10 odd years). Had echo in Sept due to palpitations/pain in left side of chest. Showed mild RAE and Moderate LAE and my RV was upper limits of normal. Have been on amlodipine and quinapril for about 6-7 years as well as other meds. My blood tests came back fine except for my RDW which is elevated. My NT-ProBNP was only at 6 pmol/L so very low. The Cardiologist immediately ruled out coronary disease - he said I was too young (40yrs old).
DCT = 73 m/s IVRT = 53 m/s (74+-7) Estimated RV/MPAP = 30mmHg EF= 60% TR Mild with Mild PAH During the test patient has Fast HR (Other all values are in normal range) except TAPSE = 28mm S wave = 14 cm/s * Fast HR was from my anxiety. Because I'm too anxious and suffering from anxiety disorder from past 5 months. The question is this, that i really have PAH or it is just misdignosed due to fast HR which put pressure on this? also my B.P was a little high 140/90 aproximately.
As you know there is an exercise and resting parameters for pulmonary arterial hypertension (PAH). The exercise parameter has a mean (average) ≥ 25 mm Hg at rest and 30 mm Hg with exercise. However, making the diagnosis of PAH can be difficult.
Pulmonary (PULL-mun-ary) arterial hypertension (PAH) is continuous high blood pressure in the pulmonary artery. The average blood pressure in a normal pulmonary artery is about 14 mmHg when the person is resting. In PAH, the average is usually greater than 25 mmHg." Quoted from the Pulmonary Hypertension Assn. Website.
Do I have all this right? Also, is there some web site that shows heart blood flow A- Z. Thanks.
So, I was a perfectly healthy 18 year old, no food allergies, and very athletic. One time, I went out to a restaurant and ate shrimp fettuccine alfredo. About an hour later, my stomach hurt (pain scale: 8/10); hands and thighs started turning red, itching, and swelling; my vision and hearing disappered completely; and I became so weak I couldn't stand. I recovered, and was fine soon after that so I never saw a doctor about it.
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