Eithne01,
The treatment of chronic myeloid leukemia (CML) has changed significantly since the late 1990s, with the development and subsequent approval by the Food and Drug Administration of imatinib (in 2001), the first of a class of medications called tyrosine kinase inhibitors, which target the specific abnormality that causes CML.
Before that time, patients were treated with other therapy, including interferon and bone marrow transplant, and had very poor outcomes.
Are you currently on any medication like imatinib? The neutropenia can be due to your current medication. You can ask your hematologist for G-CSF injection if you have persistent neutropenia. Patients with CML are immunocompromised and can easily acquire infections. Neutropenia also puts a patient in an immunocompromised state.
For now, it is very important to prevent acquiring any infection. You should avoid crowded places and persons with ongoing infection.
Good luck.
Hi.
Chronic Myelogenous Leukemia (CML) is a blood disorder caused by an acquired genetic defect in the pleripotent stem cell. It has several phases: indolent chronic or stable phase, aggressive or advanced phase, and accelerated and blastic phase. The transition between phases may take years (on the average, 4 to 6 years from the stable phase to aggressive phase).
Further, radiation to the IMN’s have been associated with increased cardiotoxicity. Therefore, even in cases where there is known IMN involvement, risk benefit ratios must be considered when contemplating therapy.
Average survival rates are generalizations, not applicable to a particular patient. The prognosis is relatively good. Newer techniques are being tried, including imatinib and stem cell transplantation.
All the best, and God Bless!
ve learned so far about epidurals is that they contain a lot of analgesics that demonstrate a lot of CNS depression and bradycardia (slow heart rate) as side effects, and not tachycardia. However, cardiotoxicity is a main concern with the drug cocktail epidural, so the best advice would be to ask your OB.
The Taxotere+cytoxan treatment eliminates the use of epirubicin or adriamycin (epi and adria carries the risk of cardiotoxicity). Whatever chemotherapy regimen you choose, make sure that you also discuss with your oncologist regarding hormonal treatment (tamoxifen) since you can derive bigger benefit from this compared to chemotherapy.
Regards.
My oncologist didn't tell me about the cardiotoxicity / renal of my chemo. I developed cardio renal syndrome. I asked him why I was filling up with fluid, my blood pressure changing etc but he never told me the chemo was toxic to my heart/ kidney and could kill me before the cancer did. He let me suffer for 2 months before my bnp was so high he canceled my chemo. Is this standard practice, to ignore side effects, collateral damage.
Her neurologist recommends the medication, Trileptal, but I am very concerned about the rare, but life threatening side effects, TENS, cardiotoxicity, etc. Keppra is alternate possible drug which seems to have a better safety profile. My question is: Are the possible psychological side effects of Keppra (psychosis is worst case senario) totally reversible if the drug is stopped?? Any insight would be appreciated!
TY for the reply. Yes I was told and am thinking that its parasitc or allergy. I went to aruba in June but that wouldn't have an affect on me now, would it?
Hi and welcome to our community!
I am sorry to hear that you have been dx with BC, but glad to hear your surgeon got clean margins and that no node involvement was detected.
A loved one of mine was dx with TNBC a little over a year ago. Her oncologist prescribed TAC and she did very well. (We had also learned that this was the chemo protocol recommended by the Mayo Clinic for TNBC.
Depending on her cardiac status, she may not be given anthracyclines like doxorubicin because of the potential cardiotoxicity of the drug. Luckily, there are other available chemotherapy drugs that can be used.
The risks and benefits of treatment should be weighed as I have already mentioned.
Take care.
Therapy with corticosteroids is used for the treatment of most and additional therapy is available and dependent upon the type of HS. Newer medicines such as imatinib and mepolizumab are said to be promising. So, should your son have HS, there is reason to be optimistic regarding a positive response to currently available therapy.
You should request, of his doctor, an additional explanation for the tentative diagnosis of pre-hypertension.
Good luck.
Vasoconstriction isnt a problem.. I did some research into the cardiotoxicity and it seems the major concern is precipitation of torsades de pointes.
Tdp is something that can in theory kill you.
But! Its also not something that lasts forever.. Once your body metabolizes the drug you're good to go. So if you havent been using it anymore you should be fine.
Worse news followed in August when unexpected cardiac toxicity was seen with BMS-986094, a nucleotide analogue polymerase inhibitor, leading to the death of a patient and suspension of clinical trials. This nucleotide was just one of a molecular family, and concerns that cardiotoxicity may be a class effect led to studies with related drugs (such as a compound in phase IIb development, IDX184) being placed on full or partial clinical hold.
Recommended
