humira vs enbrel mechanism of action

Lulu--I used to take humira, which is a TNF inhibitor like Enbrel. One of the rare side effects of both humira and enbrel is the development of MS or MS-like symptoms. I didn't pay enough attention to the warning because it seemed so remote and happened so rarely. However, it happened to me. If what I have is MS, the doctor isn't sure whether the humira caused it, or if I would've gotten MS anyway, but the humira hurried the process along.

now need to decide on a medication and have been giving the chose between the infusion and giving myself shots. My doctors seems to be leaning toward Humira shots. The idea of giving myself shots for the rest of my life is very overwhelming. My mother gives herself shots, and wants the infusion, but cannot because she would have to change medicines and her Embrel is working so the Dr. wont switch her. Does anybody have any insight to which is better.

The competition does sell versions of it (Remicade and Humira) but those are just as costly. Humira actually would cost me more. I was hoping there was a different class of medications outside those 3 that can do the same job for much less.. Thank you for replying.

I am having the exact issue you describe, except I'm on Enbrel. Just started seeing an ENT specialist to try to get to the bottom of it. The Enbrel works for my RA when I can stay on it, but then I get sinus infection and have to go back off... it's a constant cycle. Constant headache behind my eyes and sinus congestion. I take Allegra D for sinus and Bultalbital (prescribed) for the headaches, but it barely takes the edge off. Been dealing with this for years...

Most of the AS folks I talk to are on enbrel, but they are comparable meds. I hope one of them will pipe in here. Bumping this to the top of the forum will help with that effort. How long have you been taking the Humira?

does anyone know about any new medicine for psoriasis?beside dovonex,enbrel,humira.?

Hi, I also have AS, diagnosed in 2007 and have taken both Enbrel and Humira. Neither did the trick for me. Enbrel did nothing Humira gave minimal relief, it did help with my eye symptoms. I have also been on celebrex and several other medications. I was unable to get much relief with any of them, my lower back and hip would just kill me. About 9 months ago I completely stopped taking everything because they just werent helping and I just felt terrible.

My doctor wanted me to go on Remicade after only 1 month of the Enbrel. I do not have time to go for infusions and am in the process of changing doctors because we just don't see eye to eye on things. If the Humira and Remicade are the same drug then why make me travel and give up 1/2 a day to be infused. $$$$$ is why! I used to work at the practice he is at and they just started an infusion clinic, a no brainer... Money for them, inconvenient for me.

I just started Humira (2 shots so far) and have had a worsening of symptoms since the first shot. My hands/feet have become swollen and my joints hurt more than before I started taking the Humira. I also have systemic vasculitis (Churg-Strauss Syndrome) and am on Cytoxan and Prednisone, but I have been taking both for more than a year and know the side-effects from each.

I thought the intentions of each were sort of opposite of each other.

Since he is not having success with the other treatments, I would encourage him to try Humira or Enbrel. Many in this community swear by them and have had their quality of life significantly improved. Please let us know if there is anything we can do to help. Ada and I are here for both of you as are many other members here.

Despite great advances in the treatment of psoriasis,Coal tar remains gold standard as an ext application for plaque psoriasis.Steroid cremes do help,but int.steroids are contraindicated.Oral zinc is good.Cure remains yet as unachieved but then relief and remissions are achievable.

I thought I had the flu about 5 years ago.. turned out to be PMR and my joints were very painful.. could hardly walk.. it was in my feet and ankles, knees, and wrists.. anyway I took celery seed and Ibuprophen.. and it went into remission.. yeah! celery seed.. worked as well as the sterioids that others have been on.. and though I have had a flair up .. so has another person I know with it, who is still on the steriods.. so you might want to at least look into the symptoms..

Remicade is a biologic injection, in the same class of drugs as Humira, Enbrel and Orencia. I have been taking Humira for rhematoid arthritis and it seems to be doing it's job as my rheumy says. It keeps me out of the emergency room with serious flares which had become a habit for me. These drugs are usually reserved for "rheumatoid" type arthritis and getting insurance companies to approve them is not normally easy.

LOL, yes it is and thank goodness you don't have ALS. I am on one shot of Enbrel a week and the doctor I just fired was talking about putting me on Humira or Remicade. Remicade is an infusion medication and Humira is an injectable like the Enbrel. You may want to speak to your rheumy about perhaps trying one of those two. I was in between jobs and had no insurance and had to stop the Enbrel for 3 weeks, within 2 weeks the pain and stiffness was back worse than ever.

I was tried on Humira and Enbrel. They discontinued the Humira because it was not helping. They discontinued the Enbrel because of side effects. Now I am on Plaquenil. I also get Rituxan infusions.I am on 15 mg of Prednisone but being tapered because I have been on it since 2009 and they want me off it because of the problems it is causing me.I have been diagnosed with Interstitial Lung Disease and Pulmonary Fibrosis. Also Traction Bronchiectasis. I am on 5 ltrs of oxygen 24/7 for the Fibrosis.

I've just had my 2nd injection of Humira today (on 20mg, 2x month). Both times I've had no energy and felt bad for about 12 hours after the injection. Anyone else have this type of reaction to the injection?

Hi. I've had RA for 17 years, on Enbrel for the last 8.5. I never wanted to go on MTX because the side effects scare me, and I enjoy a few drinks with friends. A new doctor has put me on it in conjunction with Enbrel because I have couple joints which have been causing me problems. Otherwise, I've been great on Enbrel. I am now in my 3rd week on MTX, and seveal joints are really flaring. I find this very depressing.

Pain is listed among the side effects of Humira and this could be it. Also, since it iwas your first time to give yourself a shot, here are some pointers I found online. "...you should always position injections at least 1 inch from recently used injection sites and avoid injection into tender, bruised, red, or hard areas. When you administer the injection you may pinch the area up when giving the injection (I hope that makes sense) Also you may want to apply a cool compress afterwards.

29, 2009 - Rheumatoid arthritis patients who take the biologic drugs Remicade, Humira, and Enbrel do not appear to have an increased risk for developing cancer in the first few years of use, researchers in Sweden report. The study is one of the largest and longest population-based investigations ever into the cancer-causing potential of the drugs, known as tumor necrosis factor (TNF) inhibitors.

boceprevir is in pharmacies now telaprevir should be by the end of the month they both have the same mechanism of action ( protease inhibitors ) and are comparable in efficacy mimi that 70% is for first timers only

Still trying to get the dosages and combination of drugs right and may be going to Enbrel or Humira soon.

I have now been through prednisone, methotrexate, Enbrel, Humara(Humira? sp) then back to Enbrel.......then nothing. The Enbrel worked very well, but I have massive anxiety about the biologics. I just don't trust them and and it's very frustrating. I feel like I'm between a rock and a hard spot. On one hand they really do make me feel better, pain and ROM vastly improved.

My BD has been maintained by Humira 40Mg weekly and Imuran 200Mg daily for over a year. Prior to that Humira was bi-weekly for about 8 months and Enbrel was used for about 8 months prior to it. All in combination with Imuran 150Mg or 200Mg. During this time I have had uveitis (lasted for about 4 months) followed by gastritis (8 months), followed by strep throat leading to chronic tonsilitis and re-occuring bronchitis flares for 6 months that triggered asthma and now back to uveitis...

Hi there, My first thought is that it's the sciatic nerve being pinched or irritated in some way. Before I had my hips replaced I had pain that would start in my, um, rear end, shoot down the back of my thigh, SKIP my knee area and continue down the back of my calf. After the hip surgery the sciatic pain disappeared. My guess is that the hip pain was altering the way I walked, sat, stood, etc, which can easily lead to pain elsewhere in the body.

Yup, I definitely know about Enbrel. I was on in for over three year and wish that I were still on it. As a matter of fact, I probably will go back on it when I see my doctor in a couple of weeks. I am presently on methotrexate which is doing absolutely nothing for me. Granted, we have different types of arthritis, mine being psoriatic arthritis, but I can tell you that I was on Enbrel alone for atleast three years and I had great results with no side effects. For me it was a wonder drug.

Hi rocketship, I took mtx orally for many years and switched to injections within the last two years, along with adding Enbrel. You need a good 3 to 6 months to determine if mtx is going to work for you. I would guess that if you've experienced NO improvement at 5 months, it's time to start questioning your rheumatologist about adjusting dosage or changing meds. Placquenil never did anything for me, so maybe ask about dropping that and replacing it with either Humira or Enbrel.

Humira vs enbrel mechanism of action

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