Eithne01,
The treatment of chronic myeloid leukemia (CML) has changed significantly since the late 1990s, with the development and subsequent approval by the Food and Drug Administration of imatinib (in 2001), the first of a class of medications called tyrosine kinase inhibitors, which target the specific abnormality that causes CML.
Before that time, patients were treated with other therapy, including interferon and bone marrow transplant, and had very poor outcomes.
This is not known to be associated or found more frequently with any other disease or condition. However the enzyme involved (tyrosine kinase) is also involved in other malignancies. Malignancies either associated with or thought to be associated with activated tyrosine kinase enzymes include hypereosinophilic syndrome, systemic mastocytosis, chronic myelomonocytic leukaemia and dermatofibrosarcoma protuberans.
Hope this helps.
Initially, HIV-induced impairment of proliferation was shown to be an active process involving induction of protein tyrosine kinases in both CD4 and CD8 T cells. Furthermore, the impairment of cell proliferation was demonstrated to be linked to induction of the inhibitory protein kinase A (PKA) pathway by HIV proteins. This induction of PKA was accompanied by an increase in intracellular cAMP, which is necessary for the activation of PKA.
Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
Other possibilities which need to be explored like carotenemia(Excessive intake of vitamin A precursors in foods), riboflavinemia, use of the oral multitargeted tyrosine kinase inhibitor sorafenib and lycopenemia. You should get these possibilities evaluated from a physician.
It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
You might find he starts to be able to tolerate the pill. Gleevec is first choice for treating CML, and if he is doing good in every other way then encourage him that he is doing great.
I hope this helps you. I would be glad to help you with any other questions.
my nephew is almost 2 years old...he has high cretinine kinase level which is approximately 3000....can u please tell me whats the main reason for such a elevated ck level in a small child????
My question is...does the normal biopsy rule out CML all together? Even with the positive gene test (which I believe was positive for the Philadelphia chromosome). Any insight would be appreciated. I was in such shock when he said I didn't have CML I didn't even ask questions and I don't go back for another month and a half.
I had labs drawn and my creatine kinase was 189, my AST was 14. an my ATL was 11. Can someone Tell me is these results critical?
i get my heart checked every 2 weeks now and i am fine with the qt thing. i take the chemo pill called gleevec and have to force myself to eat so i dont get sick when i take it. how long will these withdrawel problems go on? i have xanax to take (1mg) but dont work to good. i should would appreciate any advice from any one on how to deal with these issues, family dr says its anxiety but i think its the withdrawels from the high dose of elavil.
My cousin brother is of age 9. He has extraordinary high level of ceatine kinase. About 12,000. He has had his test of polio which came negative. His only problem is that he has unbearable pain in his right calf muscle once in a year. We consulted a neurologist who told us not to worry and everything is ok. Please guide us.
This discussion is related to <a href='/posts/show/293705'>CK Levels</a>.
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