Blood levels of cyclosporine are increased if taken with grapefruit juice. A plausible mechanism involves the combined inhibition of enteric CYP3A4 and P-glycoprotein, which potentially leads to serious adverse events (e.g., nephrotoxicity).Blood levels of tacrolimus (Prograf) can also be equally affected for the same reason as with cyclosporine.
Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
I am not physically restricted - I walk 1 mile or more day and do 10 minutes of other light exercises most days. My BP runs under 120/80 most of the time. I understand carvedilol helps prevent stiffening of the heart muscle and can help restore LV function to some degree. How specially, so it do this? What is the biochemical mechanism?
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
Hi.
Response to imatinib (gleevec) can be dramatic just like what you experienced. Myelosuppression with neutropenia (decrease in neutrophils) and thrombocytopenia (decrease in platelet count) can be a side effect of treatment. Usually, discontinuation of drug intake is advised until the blood counts increase. You should have your white blood cell count repeated after 1-2 weeks and see if it already improves. You should report to your doctor if you experience any symptoms like fever.
Eithne01,
The treatment of chronic myeloid leukemia (CML) has changed significantly since the late 1990s, with the development and subsequent approval by the Food and Drug Administration of imatinib (in 2001), the first of a class of medications called tyrosine kinase inhibitors, which target the specific abnormality that causes CML.
Before that time, patients were treated with other therapy, including interferon and bone marrow transplant, and had very poor outcomes.
I realize I am no longer in remission and they will reintroduce the Gleevec when my counts reach 500. I fear that I have diastolic dysfunction of the left ventricle, which is a side effect of the Gleevec. I saw my cariologist 2 years ago and he said I had some slight thickening but nothing to worry about. I am a 44 year old male, 5'9 200lbs (I know slightly over weight).
The mechanism of action of Campral® (acamprosate calcium) Delayed-Release Tablets in maintenance of alcohol abstinence is not completely understood. Originally, several neurotransmitter systems, including GABA, were investigated for a possible role in Campral's mechanism of action. However, recent evidence suggests Campral's main interaction is with the glutamate system. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition.
http://www.nasdaq.
Plavix has a unique mechanism of action by blocking the amplification of platelet activation by released ADP, and often used with aspirin to prevent the risk of clots for the first year after DES implant. Plavix and aspirin have different mechanism of action to prevent clots. After a year, plavix is usually discontinue as the risk for clots is decreased, and aspirin is continued long term. The risk of a clot is about 3%.
He has tried Zofran, Compazene, Reglen and now a scopalomine patch. None of these have worked for him. Needless to say, he is now depressed and sleeps all the time. Is there anything else out there that can help with nausea? We wonder about the medical marijuana, but don't know if that's an option for him. What about seeing a naturopath? Any suggestions?
HIV is transmitted by;
Unprotected penetrative anal and/or vaginal sex
Sharing works with other IV drug users
Mother to child
You never had an exposure.
Potassium is a chemical element and it is part of the electrolyte that should be in balance with other lytes to adequately conduct an electrical impulse that originates with the sinus node in the right atrium. The mechanism of action is not completely understood, but what is when a voltage (unit of potential for conduction) and electrolyte there will conduction and passage of electrical impluses.
http://www.medscape.com/viewarticle/578705
Ribavirin improves early responses to peginterferon through improved interferon signaling.
Gastroenterology. 2010 Jul;139
The therapeutic mechanisms of ribavirin for hepatitis C are unclear. Microarray analyses have shown that ribavirin increases induction of interferon-stimulated genes. We evaluated viral kinetics, serum cytokine expression, and viral mutagenesis during early stages of peginterferon therapy with and without ribavirin.
Seeing an orthodontist is advised.
s because Calcium is an excitatory chemical. And guess what? Gleevec can cause low levels of calcium. So maybe both drugs together resulted in your problem with the long QT.
The offshoot is that if you ever were to go back on a higher dose of Elavil, you might want to make sure you get enough calcium. But that would only be with a doc's say so, of course. Too much potassium might be not so good - potatoes, bananas etc
Also, there is a drug that might increase appetite called Megace.
"Mechanism of Action Oxomemazine, a phenothiazine derivative, is a sedating antihistamine"
The above information is about all I could find on this drug. If it is used in the US, I have no idea what label it's under.
Even if I had been able to find more information, I am not qualified to tell you to either stop or start or change any medications. You need to speak with your doctor or chemist for an answer to your question.
, duloxetine) has a combination mechanism of action involving serotonin and norepinephrine making it useful in depression and also neuropathic pain.
When a peripheral nerve is injured there is an increase in pain sensitive fibers leading to increase pain recognition. This causes a change in central (i.e., brain/spinal cord) recognition of pain. One major neurotransmitter involved in this is norepinephrine. Cymbalta works to modulate this change.
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