Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
I have macrocytosis and my serum B12/folate levels are normal to high. However, I am showing signs of B12 deficiency with numbness in my hands and feet and pain in my legs. Is it possible to have a B12 deficiency and still have normal to high serum levels of B12?
I have been going through blood tests for over a year trying to find a cause for my macrocytosis! After my genereal physician and now hematologist number 2, we are still looking for answers. He suspects hyperthyroidim and I was hoping someone could help me and give me another opinion.
Here are my latest test results.
T4 total 12.7
T-Uptake .73
Free Thyroxin In 9.3
TSH, High Sensitive 4.272
Other abnormal results include MCV 103.2
RBC 3.76
Hct 38.8
MPV 6.5
Retic Count 2.5
Retic Absolute .
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
my sis is 28 years old her Hb is 4 her smear examined shows decrease in the RBC COUNT, moderate degree of hypochromia, moderate degree of microcytosis and mild degree of macrocytosis ,many ovalocytes,tear drop cells ,target cells and schistocytes are also seen now what to do?
You might find he starts to be able to tolerate the pill. Gleevec is first choice for treating CML, and if he is doing good in every other way then encourage him that he is doing great.
I hope this helps you. I would be glad to help you with any other questions.
Hi
Enlarged red blood cells is called as macrocytosis. It is caused by a lot of factors such as deficiency of vitamin B12 or folic acid, liver disease, alcoholism, medications (anti cancer drugs) etc.
Do write in if you need more information.
i get my heart checked every 2 weeks now and i am fine with the qt thing. i take the chemo pill called gleevec and have to force myself to eat so i dont get sick when i take it. how long will these withdrawel problems go on? i have xanax to take (1mg) but dont work to good. i should would appreciate any advice from any one on how to deal with these issues, family dr says its anxiety but i think its the withdrawels from the high dose of elavil.
Enlarged blood cells (macrocytosis) is shown up on a lab test with elevated MCV (mean cell volume). Optimum MCV values 87 to 92 cu. microns. A vitamin B12 serum range under 550pg/mL (405pmol/L) would be a confirmed vitamin B12 deficiency in Japan and most countries in Europe.
Hi,
You see Vitamin B 12 deficiency can occur without any significant anemia and with a normal CBC. However, the RBC’s are larger in size which is known as macrocytosis.
There are some tests which can pick up Vitamin B12 deficieny before actually the anemia develops. Diagnosis of vitamin B12 deficiency is typically based on measurement of serum vitamin B12 levels; however, about 50 percent of patients with subclinical disease have normal B12 levels.
t know yet if there is a connection but blood tests have revealed Macrocytosis.
I should mention that I have CML but it has been in remission for the last two years and I am no longer taking Gleevec.
I am scheduled to be looked at by a group that kills the nerve endings in the heart that causes AF but there is an 18 month waiting period.
My question is how many times can I be cardioverted and what is the downside of having it so often?
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