Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
If the Gleevec is indeed causing the hyponatremia, then it's likely this way: "Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)" https://emedicine.medscape.com/article/246650-overview
...which is from too much water being retained. This is because of what happens inside the kidneys. Has she gained a lot of water weight?
I'd first think of a Nephrologist (kidney doctor), then maybe an Endocrinologist. But Oncologists should be familiar with all of this anyway.
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
Myelosuppression with neutropenia (decrease in neutrophils) and thrombocytopenia (decrease in platelet count) can be a side effect of treatment. Usually, discontinuation of drug intake is advised until the blood counts increase. You should have your white blood cell count repeated after 1-2 weeks and see if it already improves. You should report to your doctor if you experience any symptoms like fever.
With diastolic dysfunction, depending on the severity, the body is sensitive to volume overload and can sometimes result in fluid backup into the lungs, resulting in (usually acute onset) shortness of breath. This can be exacerbated by high blood pressure. From what you are describing that your cardiologist said, your diastolic function is probably only mildly abnormal, and is unlikely to be the explanation for your occasional cough.
EXCEPT that the 1st doc was justifiably afraid that the long QT could end in sudden cardiac death. Elavil is known to sometimes cause long QT, and 150mg is a pretty high dose of Elavil.
You might think of long QT as when the heart is not firing crisply... let's say it's sluggish. That might ultimately make the ventricles of the heart get really wacky and vibrate and not pump blood.
I should mention that I have CML but it has been in remission for the last two years and I am no longer taking Gleevec.
I am scheduled to be looked at by a group that kills the nerve endings in the heart that causes AF but there is an 18 month waiting period.
My question is how many times can I be cardioverted and what is the downside of having it so often?
There is no genetic basis for the CML therefore she was not put on Gleevec. She is on Hydrea to keep the wbc count down to a more normal level. I think the only thing that led to the CML diagnosis was the extremely high wbc with no sign of infection or other cancer. Mayo did the same blood tests as the hometown doctor, as well as the lab in Iowa City. I would like them to run other tests but havent a clue what to ask for.
But the simplicity also allows people to become complacent or to ask for that little treatment pill they show in the news report without question, which we know all doctors are so well educated on treatment (insert sarcasm here). By the way, that treatment pill they show is Adefovir.
Oh yeah, I also wrote Fiona Ma to show my support for her advocacy work. Will let you guys know if I get a reply.
so I was in the mall all day . Shopping with my sis from 3-9 . I started to feel cramps but I said to myself it's normal . Although it was more painful than usual . I go home I go to use the bathroom I notice my panties felt wet I look down and I had blood all over them . I looked in the toilet and it was blood also . No clumps . But it was enough to look like I got my period it was a lot .
I'm in the hospital for a possible induction today because my daughter is measuring at 33 weeks and 3 days and I'm 35 weeks and 3 days but haven't heard any news of what they r going to do besides let me take a shower and get me walking around
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