Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
Fortunately, in the last several years, two other agents (these are referred to as second-generation tyrosine kinase inhibitors) – dasatinib (Sprycel®) and nilotinib (Tasigna©) have both been shown to be at least equally effective (and likely better) in treating CML. They have different side effects, but either can be used as initial therapy for CML or after imatinib therapy.
This may be helpful to you:
http://www.medhelp.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
There is no genetic basis for the CML therefore she was not put on Gleevec. She is on Hydrea to keep the wbc count down to a more normal level. I think the only thing that led to the CML diagnosis was the extremely high wbc with no sign of infection or other cancer. Mayo did the same blood tests as the hometown doctor, as well as the lab in Iowa City. I would like them to run other tests but havent a clue what to ask for.
i was diagnosed with cml in march of 2009 and was also taking 150mg of elavil at bedtime to control migraines for like 10 years. then this past dec. a heart test showed i had prolonged qt of the heart so i was stopped 'cold turkey' by a dr and its been down hill ever since. i have had the shakes, loss of appetite and constant nausea. i wake up evey morning shaky really bad.
I am a Leukemia Survivor also. What type of Leukemia did you have, and what was your treatment. I have CML, and have achieved a major molecular response through a oral chemo drug called Gleevec.
It does not sound like these patches have anything to do with the Leukemia. I would see a Dermatologist to have them evaluated. I hope that helps you a little bit.
I should mention that I have CML but it has been in remission for the last two years and I am no longer taking Gleevec.
I am scheduled to be looked at by a group that kills the nerve endings in the heart that causes AF but there is an 18 month waiting period.
My question is how many times can I be cardioverted and what is the downside of having it so often?
After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
In Jan WBC was still around 12 but he also performed a gene test and said the results were very suspicious. He said I had CML and scheduled a bone marrow biopsy for the following day when my husband could be with me. After 10 days I went back for the results and was told the biopsy came back normal and that I did not have CML. My question is...does the normal biopsy rule out CML all together? Even with the positive gene test (which I believe was positive for the Philadelphia chromosome).
My uncle was diagnosed with CML (chronic myeloid leukemia) His last full body checkup was a year ago and it was all normal back then. He regularly did full body checkup.
My questions are
1) Could a person get into 3rd or 4th stage under a year?
2) Is there a cure for CML?
My husband was diagnosed with CML chronic meyliogenous leukemia and hep c last sept. He started on a target therapy drug at a high dose until March of this year when he became low on blood and anemic. His oncologist claimed he had internal bleeding and sent him to the emergency room hospital. He has been in and out of the hospital 5 times in the last month, taken 13 units of blood and several units of platlets but no internal bleeding has been identified. Where is all this blood going?
Yes we called the clinic that did the spaying on both our girls and they are calling us back
My 24 year cousin is my best friend and was just diagnosed with CML and her doctors are very optimistic, but she has so many qiestions she is scared to ask. They are going to put her on the "Miracle Pill" will she lose her hair? Will is hurt her chances of have children? As optimistic as the doctors are, is there any chance that this is a fatal condition?
We are scared should we be?
So now I am really scared, and do not know what is causing this high neutrophil count. I came across CML - and the article mentioned several things:
1) Alot of people do not feel any symptoms at the start
2) They became diagonosed off of a routine blood test
So I am starting to think that this is it. My doctor is on vacation and will be back next week. But what do yo guys think? I can't seem to come up with any opther explanation (except my smoking perhaps).
I have been diagnosed with CML since Novmber of 2007. I am still a little confused about some things. and i guess when my WBC's got back to 4.5 I was excited and thought I was all good- In the clear huh... Well in less than a month my WBC's dropped back down to 1.8 and they say that I am good as long as I don't go past 1.5. Ok fine. I don't go back for another month and I already feel like **** and have had pneumonia 2x in the past month.
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