Fluvastatin solubility
Common Questions and Answers about Fluvastatin solubility
lescol
The VA [ Veterans Administration ] has looked into using fluvastatin as a treatment for HSV with some impressive results. One patient had a 1/50th load count after 4 weeks of treatment. Some others showed dramatic reductions in load counts also. Has anyone out there tried this treatment ? It does have FDA approval as a treatment for high blood pressure. VA looking for effective treatment for drug resistant HCV infections.http://www.ncbi.nlm.nih.
Accordingly, Plavix may interfere with the metabolism of phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin, and many non-steroidal anti-inflammatory agents, but there are no data with which to predict the magnitude of these interactions. Caution should be used when any of these drugs is co administered with Plavix.
Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs. Methadone has a typical elimination half-life of 15 to 60 hours with an average of i would say about 22. However, metabolism rates vary greatly between individuals, up to a factor of 100 ranging from as few as 4 hours to as many as 130 hours, or even 190 hours. So it's hard to say.
The water solubility of bilirubin allows the bilirubin to be excreted into bile. (Bile then is used to digest fats.)
Total bilirubin, if I remember correctly, is the conjugated hemoglobin, since there is also another portion that is not conjugated.
What the elevated total bilirubin means at this point is 'something' is going on, but you may need more information before your doc can determine the cause.
If you are going on a statin - which are safe for people with Hep C, by the way - you might consider asking for fluvastatin, which has been shown to inhibit HCV replication in vitro, and has the same efficacy and heart protection as lipitor or crestor.
Congrats on svr and Good luck!
There is currently a Phase II study going on with Fluvastatin along with regular SOC treatment and because Fluvastatin, like Alinia, is already an approved drug, it would be available sooner and more easily than the PI drugs, for example, currently in trial.
http://www.hepatitis-central.com/mt/archives/2008/04/fluvastatin_low.html
These links really made me sit up and take notice.
The main requirements for them are (1) high IFN-inducing activity, (2) absence of side effects, (3) wide spectrum of antimicrobial activity, (4) broad therapeutic security and, (5) good solubility in water and biologic liquids. IFN inducers stimulate IFN production in different cells and organs, and that determines the strategy for their application. Amixin (OOO "Lancepharm," Moscow, Russia) induces IFN-?/? production mostly in T cells. Cycloferon (NTFF "Polysan," St.
However, factors that can affect absorption include oral pH, salivary enzymes, lipid solubility, and molecular weight (molecules may be too large to pass through the mucous membranes). A sublingual product, specifically created to ensure effective absorption, is recommended.
A year ago, my doctor gave me Lescol/Fluvastatin to take because I am a high risk for heart disease due to genetics and diabetes. At that time my Lipids were within normal range. After a month, ALT/AST results were very elevated.
and medication was discontinued. Since then, I've gone through ultrasound, HiDa Scan and finally diagnose of fatty liver. The Gastroenterologist recommended Liver Biopsy to check for liver damage.
Lipitor (atorvastatin), Lescol (fluvastatin), Mevacor (lovastatin), Altoprev (lovastatin extended-release), Livalo (pitavastatin), Pravachol (pravastatin), Crestor (rosuvastatin), and Zocor (simvastatin). Combination products include: Advicor (lovastatin/niacin extended-release), Simcor (simvastatin/niacin extended-release), and Vytorin (simvastatin/ezetimibe).
The new labels will warn patients about:
Memory loss and mental confusion.
The same enzyme also is responsible for the metabolism of phenytoin (Dilantin), tamoxifen (Nolvadex), tolbutamide (Orinase), torsemide (Demadex), and fluvastatin (Lescol). Although important interactions between clopidogrel and these drugs are unlikely, interactions should be looked for carefully.
You should consult your doctor to insure the degree of blood thinning is within specification with INR.
well there is clinical trials for something called vx-950 or vertex 950 that is used in combination therapy with the already existing interferon or ribaviron/ roche brands are pegasys and copeagus
there has also been advances made with a already approved drug called Fluvastatin in conjuction with interferon and ribaviron that studies show have a better success on lowering viral load.
Red yeast rice, which contains lovastatin, should also be avoided during treatment with telaprevir. Fluvastatin, pravastatin, pitavastatin, and rosuvastatin are probably safer alternatives, since they are not metabolized by CYP450 3A4. All patients treated with HMG-CoA reductase inhibitors should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.
(By the way, although losartan is currently being researched in Johns Hopkins clinical trials, other ARBs such as telmisartan are probably most effective given their increased lipid solubility and thus increased tissue penetration.)
I strongly encourage you to visit www.marfanlife.net and find the very lengthy thread titled "Losartan" or something to that effect. Probably some of the most important reading of your life.
the brain is affected quickly as alcohol will cross what is called the blood-brain barrier due to its solubility. this can compromise involuntary actions such as heartbeat, breathing and gag reflex. organs such as the liver and pancreas can suffer tissue destruction resulting in everything from lowered function and scarring to complete organ failure. for diagnosing existing damage, your doctor can order bloodwork including a liver panel to check things like enzyme levels.
The other thing is Fluvastatin, a cholesterol lowering drug that has apparently lowered the viral load in some Veterans from OK. The Dr. is Ted Bader. and he is the director of OK health Science Center, his idea is to use it with interferon to completely get rid of the virus, but it was successful in lowering the viral load alone....just not clearing it all the way. Is the drug you are talking about still have bad side effects?
pdf
good article about the use of fluvastatin with hcv, as regards hbv simvastatin and lovastatin are the only statins i have seen studied on hbv (among the two sim at 80mg has the strongest effect)
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