Please note Tenofovir is principally cleared through the kidney and dosing adjustments due to renal impairment have not been clinically tested.
The followings are extracts from the label information for Tenofovir:
2.3 Dose Adjustment for Renal Impairment in Adults
Significantly increased drug exposures occurred when VIREAD was administered to subjects with moderate to severe renal impairment [See Clinical Pharmacology (12.3)].
I am not aware that impaired renal function precludes treatment for HCV. I have read that kidney disease is a negative predictor of SVR but, so too are a lot of conditions yet people have overcome them. I have seen articles which discuss the plasma levels of ribavirin with renal impaired patients. The suggestion is that rather than weight base dose these patients the dose should be arrived at by considering GFR (glomerular filtration rate).
This is from Clinical Care Options @ http://tiny.
By "AGE" I'm assuming you mean a persons age in years. I don't believe age has anything to do with Janumet's "effectiveness" but age has a larger role with renal function. To make it clear for other readers, Janumet is combination of two drugs; Sitagiptin and Metformin.
This a brief from the Merck web site - makers of Janumet - Section 8.5 - Geriatric Use JANUMET.
I also have kidney damage from a bout of high blood pressure 4 years ago, and I am a frequent kidney stone former, so I am being watched carefully by a nephrologist too. I have renal panels frequently too. I was wondering if any of this could increase my stone risk. I was reading about the cytomel and stones. The nephrologist wants me to remain on the synthroid and cytomel.
I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference:
According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.
Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required. The normal ranges of GFR, adjusted for body surface area for males is 70 ± 14 mL/min/m2 (56-84) . Risk factors for kidney disease include diabetes, high blood pressure, family history and older age.
Take care and keep us posted.
Has anyone ever taken fluconazole? It's a tablet you take (only one) for yeast infection. My pharmacist said it's not for pregnant women but when I called the doc and told him what the pharmacist said he said it was ok to take. Has anyone else been prescribed this? I'm worried.
my dr gave me fluconazole for my infection ,3 pills in 3 days .should we skip or take it regular.because she told me take it wednesday ,thursday ,and sunday,,thank..
There are preferred opiates drugs that are use in patients with liver disease that have shorter half-lives and have less harmful side effects on the renal system. Your liver doctor should be aware of these drugs and be able to determine if you may be able to use them.
With regards to OTC medications, normal recommended doses of acetaminophen can be safely given to patients who suffer from cirrhosis in the short term.
You can ask your vet to prescribe an antibiotic like cephalexin and an antifungal like fluconazole both which can be called into a walmart in your area and they are on the $4 generic list so it keeps cost down. As for itching they can have antihistamines WITHOUT DECONGESTANTS in them.
But regarding this Vit D , should i need to take along with calcium supllements Or no need? I have renal stones of 0.5mm. Does this have any effect on this?
If you are stage 3 you can take any analgesic within dosing limits. Your liver function has not been altered by your liver disease yet. If you become stage 4 (cirrhosis) then you will have to modify what drugs you can take because the liver is no longer able to process drugs in a normal manner.
Tramadol is an synthetic opiate and should not be taken for "mild" pain.
Anyone ever take fluconazole 150mg oral pill for a yeast infection in their first trimester. I phoned a pharmacist and he said it was fine and all the research I've done says as long as it's not in high doses the baby should be ok, but I am having some major anxiety.
Call your local pharmacist. We at MedHelp are not allowed to give out dosing instructions. Your pharmacist will be able to tell you exactly how to dose the medications. If your regular pharmacy is closed on Sunday, call any pharmacist availabe at your local grocery store or drug store such as Walgreens, CVS, or RiteAid.
Sure, it is safe to take. I personally like the one day Monostat ovules for yeast infections but fluconazole works really great. Hope it clears it up quickly!
I've taken Clindamycin and fluconazole to kill a yeast infection. But now my doctor tells me I might possibly get it back because antibiotics can cause yeast infections. I'm not even sure...
RENAL RISK
TORADOL is CONTRAINDICATED in patients with advanced renal impairment and in patients at risk for renal failure due to volume depletion (see WARNINGS).
RISK OF BLEEDING
TORADOL inhibits platelet function and is, therefore, CONTRAINDICATED in patients with suspected or confirmed cerebrovascular bleeding, patients with hemorrhagic diathesis, incomplete hemostasis and those at high risk of bleeding (see WARNINGS and PRECAUTIONS).
ROXICODONE® is intended for use in patients who require oral pain therapy with an opioid agonist. As with any opi-oid analgesic, it is critical to adjust the dosing regimen individually for each patient (see DOSAGE AND ADMINISTRATION).
Use of ROXICODONE® is associated with increased potential risks and should be used only with caution in the following condi-tions: acute alcoholism;adrenocortical insufficiency (e. g.
Based off the symptoms I was having they told me that I had a yeast infection-(I had one about three months ago). They prescribed me fluconazole. I took it and felt better, but went back into my gynecologist for a follow up on Thursday(my symptoms were almost completely gone at this point.) They took a swab and said it the results said no it wasn’t a yeast infection, but she said yes she was sure I had had one. I took she told me to take the second dose of fluconazole, which I did that day.
but after a week i started oral fluconazole with terbinafine cream.after few days again some fungal infection came...is it the side effect of fluconazole. ???
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