The presence of a single transverse palmar crease can be, but is not always, a symptom associated with abnormal medical conditions, such as fetal alcohol syndrome, or with genetic chromosomal abnormalities, including Down syndrome (
chromosome 21), cri du chat syndrome (
chromosome 5), Klinefelter syndrome, Noonan syndrome (
chromosome 12), Patau syndrome (chromosome 13), Edward's syndrome (chromosome 18), and Aarskog-Scott syndrome (X-linked recessive).