Lyrica USE IN SPECIFIC POPULATIONS
Pregnancy
Pregnancy Category C. Increased incidences
of fetal structural abnormalities and other manifestations
of developmental toxicity, including lethality, growth retardation, and nervous and reproductive system functional impairment, were observed in the offspring of rats and rabbits given pregabalin during pregnancy, at doses that produced plasma pregabalin exposures (AUC) ≥5 times human exposure at the maximum recommended dose (MRD) of 600 mg/day.