No Detectable Resistance to Tenofovir Disoproxil Fumarate (TDF) Following up to 240 Weeks of Treatment in Patients with HBeAg+ and HBeAg- Chronic Hepatitis B Virus Infection
P. Marcellin1; E. Heathcote2; A. Corsa3; Y. Liu3; M. D. Miller3; K. M. Kitrinos3
1. Hopital Beaujon, University of Paris, Clichy, France.
2. Toronto General Hospital, Toronto, ON, Canada.
3. Gilead Sciences, Inc., Foster City, CA, United States.
At a very high vl a combination with entecavir until undetectable status would normally be preferable, but this is not possible with entacavir, a drug that holds the potential to be integrated into the genome and cause permanent mutations. This is not the case with tenofovir and emtricitabine.
I was also a reciever. After 40 hours I went to the first clinic and they gave me PEP (TenofovirDF, emtricitabine + lamivudine). The clinic looks very unprofessional, but it was my only chance. I didn't do any hiv or std test, a month before the exposure i had HIV test which was negative. After few days I had a mild sore throat, i still have it, i don't have fever, running nose, rash or anything else. My questions are..
An international study found the antiviral combination of tenofovir and emtricitabine (Truvada) was most effective in treating younger adult hepatitis B patients with high viral load and normal ALT levels.
Doctors historically have not treated this group because there appeared to be no sign of liver damage. However, doctors now know that high viral loads may increase patients’ risk of liver damage and cancer as they age, despite their normal ALT levels.
thank you
What are my chances of getting infected. Another question was administered a PEP drug emtricitabine and tenofovir, can it prevent me from contracting HiV.
combo have no effect on hbv but more toxicity on you, if you have no resistance mutations baseline go for tenofovir only or tenofovir plus lamivudine which are the less toxic/more potent and retry interferon in 3 years
FTC is Emtricitabine.
This is a potential concern because the drugs in Truvada – tenofovir and emtricitabine – are active against HBV as well as HIV.
HIV and HBV are spread through some common transmission routes, including sexual transmission, vertical transmission (mother to child) and via multi-person use of injection equipment.
I asked her of her status and she stated clean. I started PEP within 24 hours. (Teneogovir, emtricitabine, lamivudine ) What are the odds of being infected ? is this low risk ?
I started a course of PEP that included Tenvor-EM (Indian version Emtricitabine/Tenofovir DF) and Kaluvia (generic of lopinavir/retonavir) for 25 days and interrupted it for two reasons:
1-My partner tested Negative(Antigen/ Antibody) on 22 days post exposure
2-Thinking that i might be developing facial Lipodystrophy (slight facial fat loss under cheek bones). I cant tell if my face was like this before the treatment or it is just an illusion.
Pai I 5g/5g; HPA 1 1a/1a; ACE del/del;F XIII homo V34L; Beta Fibr. Hetero 455G>A. Fibrinogen (now): 11,8. I 'm a little positive to ASMA (1:40), and I have, sometimes, erythema, so i take also prednisone. I'm sure that I find causes of my miscarriages, but I'm searching for studies or news/statistics about my situation, specially about mthfr homo A1298C, because there are many confusion ...So I ask: Is my condition actually miscarriage's cause?
Hello, I am a 58-year old woman of Ashkenazi Jewish heritage. I have never had cancer, my Mother is alive and well at age 80 and has never had cancer and my Grandmother never had cancer during her lifetime. They both had hysterectomies in their forties due to large fibroid tumors which I never experienced (I've always attributed that to the fact that I was on the birth control pill for over 15 years). My fraternal twin sister had a hysterectomy in her early 40's for the same reason.
I do believe if your mom had certain mutations and then transferred HBV to you the mutations (and genotype) transfer.
The virus/immune system reaction can also make new mutations along the way. So, your mom may or may not have the same as you, if you've made new ones. Your mutations are common in escape hbeag negative viral load above 2,000 iu/ml, genotype C (taken from your other post data).
htm
19
Dec
Establishment of a Novel Assay for Detecting Mutations Associated with Antiviral Resistance of HBV Covalently Closed Circular DNA and Its Application
posted by: Tumor Research
[Abstract]
This research was composed of two parts:Ⅰ. Establishment of a novel assay for detecting mutations associated with antiviral resistance of HBV covalently closed circular DNA.Ⅱ.
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