I used
Avonex for 396 shots (7+ years), and after going to Gilenya on Halloween I’m going back to
Avonex this month.
The flu-like side effects of Avonex are most common, but often easily minimized. Some keys are to keep hydrated, inject in the afternoon or evening (preferably Fri/Sat if you work a standard week) and use drugs such as Tylenol, Advil, Aleve, etc.
For me the side effects lessened over time. However, I know of others that found them intolerable.