avonex neutralizing antibodies

I don't know whether this addresses your question but it seems related. See: Immunotherapy for HCV Infection: Next Steps Posted 11/04/2008 http://www.medscape.com/viewarticle/581892_1 "....While it is known that neutralizing antibodies are generated during HCV infection and that they can be detected within 7-8 weeks postinfection.[27] they are not able to protect against reinfection.

I was diagnosed almost 4 years ago-my first initial symptoms were left leg weakness/heaviness, being very tired , facial numbness and tingling in my rt arm. I started avonex and the flare lasted about 3 months.

Pure Red Cell Aplasia •Cases of PRCA and of severe anemia, with or without other cytopenias that arise following the development of neutralizing antibodies to erythropoietin have been reported in patients treated with PROCRIT®. This has been reported predominantly in patients with CKD receiving ESAs by subcutaneous administration. PRCA has also been reported in patients receiving ESAs for anemia related to hepatitis C treatment (an indication for which PROCRIT® is not approved).

So, first thing is he wants to check to see if I have neutralizing antibodies to the Avonex. If I do and they are in high titer, then there is no sense in continuing with the Avonex or any other Interferon-beta. The test for antibodies is highly specialized and done by very few labs. The one he trusts is on the East Coast and it costs $1000. It sounds like Medicare will cover it (????) We'll see.

What does NEUTRALIZING EFFECT and PRONUNCED EFFECT mean .My neurologist is on vacation.The results are from a meningiona on 4/2010.I dont have any knowledge of what the effects mean.If you could write what each one means it would be greatly appreciated.

One of the new antibodies, AR4A, shows broader HCV neutralizing activity than any previously reported anti-HCV antibody. "These antibodies attach to sites on the viral envelope that were previously unknown, but now represent promising targets for an HCV vaccine," said Mansun Law, an assistant professor at Scripps Research. Law is the senior author of the new report, which appears online this week in the Proceedings of the National Academy of Sciences.

Thanks ABX203 has been designed to induce the production of neutralizing serum antibodies to HBsAg and the induction of strong cellular responses which are weak or undetectable in patients with CHB. These immune responses are similar to those that occur in patients with a self-resolving acute HBV infection.

I found out today that (my Nuero speaking now), I am positive to binding antibodies but negative to blocking antibodies. This may be his way of saying its low. I asked about the titer and he said 0. Told me to stay on Avonex and retest in August. If I increase on the blocking side, which he said may happen then I will have to look into another therapy. He said that this is the typical pattern of developing the NABs and that I could go either way at this point.

ve not seen the results of these studies (from MSAA site) *************************** Spring 2008 Research Update May 19, 2008 A one-year study in Germany found that 1157 patients with relapsing-remitting multiple sclerosis (RRMS) who began and continued on Avonex® for one year, benefited from nursing support. They also experienced a modest improvement in quality of life during this treatment period, as measured through the EuroQol questionnaire (EQ-5D).

"Copaxone decreases relapses the least and has very painful sting to shot and welts. " I'm not sure where that data came from. All of the CRABs seem to have a similar effectiveness in the 30% range as far as reducing relapse. In my case, as long as I inject manually, I don't really get a very painful sting or welt, just some minor itching for a half hour. I don't have to worry about liver function tests, neutralizing antibodies or depression.

Despite my feeling that my arm is weaker, he says my exam is unchanged and my neutralizing antibodies were negative. So everything is to remain unchanged. Avonex plus once a month steroids. Repeat the MRI in Janurary. I will have OCT next week - Optical Cherence Tomography. OCT measures the thickness of the optic nerve as it spreds out in the retina (forming the optic disc) and goes to all the light receiving cones and rods.

I'm just wondering if I'm the only 1 who feels like Avonex is destroying my immune system. Shortly after starting the injections a yr. and half ago, I've been getting sick a lot, & each time is a big deal. I've never in my life been on so many meds., such as antibiotics & steroids, and with little relief. I've decided to stop the Avonex. My m.s. (which I believe is mild) is fine, mri's are unchanged from the 1st one. I want to see how the next mri's look.

gov/pubmed/22581898 Spontaneous clearance of chronic hepatitis C virus infection is associated with appearance of neutralizing antibodies and reversal of T-cell exhaustion. Raghuraman S, Park H, Osburn WO, Winkelstein E, Edlin BR, Rehermann B. Source Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Department of Health and Human Services (DHHS), Bethesda, MD, USA.

This is to possibly calm down the immune system and lower the Antithyroid Peroxidase antibodies. I take a multivitamin which provides 100 mcg selenium and eat well, so I probably get at least 200 mcg selenium in my diet each day. I know there is a toxicity to selenium, so I am wary of taking it in addition to my vitamin and food. Also, I did have my selenium levels done, and the result came back great - high normal range.

ABX203 is designed to induce the production of serum neutralizing antibodies against HBsAg and the induction of strong cellular responses. These immune responses are similar to those that occur in patients with acute hepatitis B infection and can heal spontaneously. ABX203 being applied as a nasal spray and also as a solution for subcutaneous injection, both treatments with 24 weeks.

Hi, I was recently diagnosed with MS and had my first Avonex injection Friday. Friday night was tough (fever, chills, pain and eventually heavy sweating) but I felt pretty good by Saturday morning. Saturday afternoon I started feeling kind of down and by Sunday morning I feel even more so. I can't decide if this is a result of the drug or just the situation as a whole.

Avonex neutralizing antibodies

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