In the early breast cancer clinical trial, the most common side effects seen with ARIMIDEX include hot flashes, joint symptoms (including arthritis and arthralgia), weakness, mood changes, pain, back pain, sore throat, nausea
and vomiting, rash, depression,
high blood pressure, osteoporosis, fractures, swelling of arms/legs, insomnia, and headache.
Patients taking ARIMIDEX were less likely than those taking tamoxifen to stop treatment because of side effects.