Dr. Goodman- my Ca125 appears to be rising & my doctor has put me on tamoxifen. I know this is used in breast cancer pts but what is it used for in ovca pts? My recent PET/CT scan did not show any recurrent disease.
Dear river1980, Both Femara (letrozole) and Arimidex (anastrozole) are aromatase inhibitors used in the treatment of hormone receptor positive breast cancer in post menopausal women. Aromatase inhibitors block the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. In the absence of estrogen, tumors dependent on this hormone for growth will shrink.
i. symptoms be a side effect of anastrozole (arimidex)? I have been taking it for 3 1/2 years, after 1 year on tamoxifen, following lumpectomy, chemo and radiation.
Thanks for any feedback,
Laurie .
I was diagnosed with T2N0M0 breast cancer and went for mastectomy followed by 4 sessions of Taxotere. Now my doctor prescribed Aromasin alone for 5 years. He did not give me Tamoxifen first followed by Aromasin, but just Aromasin for 5 years. Is this acceptable ? I am 57 years old, mother of 4 children.
Please advise.
i. symptoms be a side effect of anastrozole (arimidex)? I have been taking it for 3 1/2 years, after 1 year on tamoxifen, following lumpectomy, chemo and radiation.
, locoregional or distant recurrence or contralateral breast cancer), postmenopausal women with hormone receptor–positive breast cancer should consider an AI, either as primary adjuvant therapy for 5 years or sequentially after 2 to 3 years of tamoxifen to yield a total of 5 years of adjuvant endocrine therapy. Women who discontinue initial AI therapy before 5 years should consider using tamoxifen to bring the total duration of adjuvant therapy to 5 years.
Now endo is suggesting that in order to give him more time to grow, we give him Anastrozole. I have seen lot of posts and spent hours on the forums wherever I found mention of advanced bone age/Anastrozole/Letrozole. It seems there are quite a few posts under Pediatric Endo forum but not able to find any answers if any parents tried Anastrozole/Letrozole and what has been their experience regarding delaying bone age and side effects.
Have developed a heart rhythm disturbance, shortness of breath, edema of hands and legs/feet since being on Anastrozole. How worried should I be? Should I consider discontinuation discussions with my Dr.?
This discussion is related to <a href='/posts/show/542261'>Can Arimidex Cause Skin Lesions?</a>.
I have been on Anastrozole for year, 4 more to go (5 ys.) I have the worse Joint pain, stiffness, hurts to walk, get up from chair, I get out of bed hurting, I ache everyday. My skin and stays so dry, my hair grew back after chemo, but is lifeless, thin, etc. I do not like this Pill and want to discontinue, but my Oncologist said it is doing me more good, to keep taking it. This pill is really aging me, dry wrinkly skin, no energy, cant walk and move like I want to.
I am 63 and just diagnosed with Stage 1, ER/PR Positive, node negative invasive ductal carcinoma. My oncologist is in the process of deciding whether to prescribe Letrozole/Femara or Anastrozole/Arimidex. What considerations factor into which of these two drugs to use? Has anyone had experience with either of them? How serious are the side effects?
im on anastrozole.
The oncologist switched me to Anastrozole but the Anastrozole failed. My mom passed away at the age of 97 from omentum cancer. We didn't know she had cancer until 2 months before she passed. It's a very slow growing cancer. We had no idea and had never heard of omentum cancer before but we were later told It's a metastasis from the ovaries. My recent telehealth appointment with Sloan-Kettering the oncologist suggested exemestane Hormone blocker. Wishing your mom the best.
If you've had Hashimoto's for that long, have you also been on any replacement thyroid hormone medication? If so, what medication, dosage and for how long?
Have you had Free T4 and Free T3 tested to determine actual thyroid hormone levels? If so, what are their results, with reference ranges?
I've read that there's a connection between breast cancer and thyroid disease, but I'm not exactly sure what it is.
As of right now we are holding off on meds. He is growing but still just a little each year. He hasn’t hit a growth spurt yet but I’m hoping he does very soon. My son is 4’6” now and I worry so much that he is not going to reach anywhere near his mid parental height. How tall is your son? We have seen an endocrinologist who thinks anastrazole would be a good way for him to get closer to his potential, but I am so scared to put him onedicines just to gain a few inches.
My son is on GH for GHD. Also did 2.25 yrs anastrozole since bone age was slightly ahead. Now only on GH. Age 15.5, bone age 13.5-14. Has all the puberty markers for tanner 4: pubic hair now starting a line to navel. Has to shave a couple times per week but only few hairs in beard area, voice deeper but no prominent adams apple yet. A year ago at endo appt we were told he didnt have to endure anymore testicle size checks. I assume that means they are near adult in size.
Today the results of the Oncotype DX was 8 and the doctor gave me Arimidex (anastrozole) 1mg tablets and I am scheduled to see the radiologist next week. I think with all the side effects of the medicine, it sure is scary, but I will try it. If it gets me sick or if I am unable to take it, then I won't take anything. I also want to see what the radiologist suggests as far as how many tx's I will need to take. I guess time will tell.
I have been on Tamoxifen for a little over two years for breast cancer. I am 46 and pre-menopausal. The first 22 months on the tamoxifen I had my period and occassional hot flashes. then one month my period stopped and my hot flashes. At month 27 on Tamoxifen, I had an ultrasound that shows a lickening of the uterean wall and 3 complex ovarian cysts. My Dr. is doing a biopsy but my question is why would my periods AND the hot flashes go away completely?
You're talking about Tamoxifen and Paxil used at the same time, yes? It has been proven that certain SSRI's which is what Paxil is do stop the benefits of tamoxifen.
From Pharmacist's Letter's: July 2009, vol 25, no. 7
"You'll see new warnings not to combine tamoxifen with certain SSRIs..paroxetine, fluoxetine, and sertraline. .... Women have a higher risk of breast cancer recurrence if they take tamoxifen along with paroxetine, fluoxetine, or sertraline...
Hi, I am a 27 year old woman who was diagnosed with breast cancer at age 25, I had a complete mastectomy and given the option of chemo or tamoxifen, we picked tamoxifen becasue being able to have children is very important to us. I have been taking this for just over one year and I had MANY side effects to tamoxifen, so much so that I have considered stopping it.
I don't know about Femara but I have gained weight on Tamoxifen. I get to stop taking it next month and I can't wait to see if I lose some of this weight.
It seems to me that there is a lot more risk in taking tamoxifen for 5 years -then 5 - 8 weeks of radiation therapy, if that's the case, why would tamoxifen be recommended over radiation?
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