I am partially on Vyvanse because I cannot take any antidepressant whatsoever, which occurred about three to four years ago. No clue why. Thus, off Vyvanse, my depression returns to baseline. However, like many people with ADD, Vyvanse does not agitate me but rather calms me down. Thus, I suppose the answer could in part be a rebound effect in the case of both anxiety and depression? However, the morning attacks seem anxiety related.