tysabri liver

Hey everyone went to my neuro today we are stopping tysabri due to liver enzymes elevated for last 3 months. Went to a GI specialist to rule any liver problems out and after all sorts of testing seems like tysabri is the likley cause. I will start tecfidera in 3 months I hope I dont have the rebound effect I have heard about after stopping tysabri. Tysabri has really changed the way I feel was using a walker now nothing and I do Zumba too. I hope I stay like this but having doubts.

I just started Rebif again this week on a very gradual titration schedule, and my liver will be monitored closely via weekly labs. If my liver enzymes elevate again, I will need to go off of it. My neuro has described my early MS as 'very active.' Last Sept, my MRI showed 1 brainstem lesion and 1 C-spine lesion. 8 months later my MRI still shows the same brainstem lesion; it does not show the previous C-spine lesion, but does show 3 new lesions on C-spine.

I was on tysabri for 9 months till my liver decided it didnt like it anymore but I loved the drug went from using a cane to nothing. I just started gilenya yesterday so jury still out on that. Its been 7 months since being off therapy and feel like crap the fatigue is overwhelming and my balance is bad dragging foot again so should be using cane again just not mentally ready for it. if your jc neg I would go for the tysabri as long as insurance covers it 1 hr a month and done so easy.

Hi all, My TOUCH center DOES monthly CBC, CD4 counts and liver function tests as a routine part of the Tysabri infusion experience. We see mid level practioners (MS Nurse Practioners) or the MD on a rotating basis so every 3 months I see the MD. Tysabri can cause liver dysfunction so they feel the testing is necessary to catch any developing trends. the CD4 counts and CBC they use to track treatment effectiveness.

I have failed rebif and my liver didnt tolerate tysabri after 10 infusions. I really didnt like the side effect profile from tecfidera and was hoping this was gonna get approved.

Last week I started my 3rd significant relapse this year, my specialist nurse is now talking about Tysabri. I was on Rebif for about 15 months and wasnt getting on with the side effects so I switched to Copaxone 6 weeks ago, which I'm quite happy with. I looked up Tysabri when I got home and all I got was all the bad news about the PML patients. They say that theres a 1/1000 chance of getting it, that seems quite high to me.

Which (CRAB/Tysabri) medication do think has the least side affects? Please vote because this poll is for an individual trying to make a serious decision, and the doctor told this person to choose their own treatment.

Friday I called my neuro to find out if they want me to do a washout period on Tysabri, as they are considering me for the new drug out in March. I've ben on Tysabri almost a year and JC+ from the start The nurse told me my test showed 1.03. which means nothing to me. Anyone know anything about this test?

Hope everyone is well. I just wanted to give an update. I had my first Tysabri infusion this morning and I experienced no side effects so far at all. Over the last 2 months I have had some improvment. I still have all my symptoms but they're less intense. So here's hoping for the best. Hoping this medication works at seriously slowing this beast way down. How are things with everyone? I truly hope everyone has been well or well as can be expected.

Not to mention, that I will soon run out of good sites. I am a bit afraid of the Tysabri. Though she says there have 6 or so episodes of PML, some were Europe where they don't have the Touch program and pt are not followed as closely. She says 83% of users have no flairs in a 2 year study. She will see me monthly or sooner of course if necessary.

Janine, Wishing you well with the new oral med. Like Daisy girl, I was given the options for Tysabri and Gilenya. I will be doing Tysabri, for 1 year. If not doing what it "should" be doing, I will then most likely start Gilenya.

Didn't they just find something else as a side effect of Tysabri? Like a liver disorder or something?

Most DMDs do not suppress the immune system Tysabri can make you more suceptible to the JC virus. Gileyna to herpes. The CRABs do not make you more suseptible to illness. They all have different mechanisms to keep your immune system from attacking your T and B cells. Each works differently. Some block the action, some act as decoys, etc. It is confusing. Each person with MS is different. I for one am pretty healthy from infections.

It's 99% official - they are taking me of Tysabri - my allergic reaction (GI difficulties) was getting worse. My neuro drew blood for an antibodies test - he thinks my body has developed antibodies to fight Tysabri, and if that be the case, I am 100% off of it. So am taking a "holiday", knowing the rebound I am facing, to recover. We will make a final decision when the blood test come back.

s neuro appt as I am sure he is either a) going to try to talk me into staying on Tysabri (noooooo as I hide under the covers) or asking me what my 2nd choice is (???) but am clueless. I KNOW I don't want anything with the word NAUSEA associated to it in any way. Anyone want to give me their experience. I'm not shot shy, have given too many of those, just being whimy and wanting as few side effects as possible.

I was diagnosed with relapsing a remitting ms 1 yr ago. I had a very aggressive doctor that put me on Tysabri infusions even though I had never tried anything else. After research and being so terrified of the brain infection which causes severe disability or death I changed doctors! I have been on Aubagio, the new pill, for 1 month and have not had any problems. I emptied my hair brush the first day to see if I would have hair loss, which there is nothing out of the ordinary.

Well I saw my neuro today and after a lengthy discussion with both him and the nurse, the subject of UTI did not come up! There was so much else to cover, I completely forgot to ask and they apparently did too. Argh. Why didn't I write it down? No 12 year old resident this time lol so it was nice to get to know my neuro better. We had a long discussion about changing treatment.

3 fever and someone I only know briefly in passing, has liver disease stemming from the Tysabri, so yeah, I want off of it. It doesn't appear to be working as well this year. You are going to love your trip, Alex, I wish you the best on it.

Here is what my neuro had to say about that, as many of you told me, many people who are JC+ take Tysabri. He explained that the TOUCH program allows them to monitor patients making it much safer. He did however tell me that I would be allowed to stay on Tysabri for only a year at best. Then he told me that although people feel great on it, as soon as they stop taking it they "crash and burn", meaning they feel terrible and begin having many relapses. Well that sure turned me off!

Hi I had my port a cath put in 2 weeks ago for my tysabri infusions it wasnt too bad they didnt want to put me to sleep because of the ms and the swallowing issues so some versed and locals and it was done. Last thursday I had to have a blood draw my neuro wants liver tests a week before every infusion so they used the port well omg and other words it hurt like nothing I have felt before in regards to needle sticks that is.

They found out the reason people contracted PML was because they were taking Avonex/and the other MS medications with Tysabri. I think the Tysabri has given me a second chance at helping slow my disease progress, but with out it I would be on no MS medications to slow the disease. I did alot of research before I decided to start the medication and the one resource that helped me make my decision was reading the Tysabri diaries on line. www.msrc.co.uk/index.cfm?

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tysabri