Serotonin Syndrome Risk
The development of a potentially life-threatening serotonin syndrome may occur with
use of <span style = 'background-color: #dae8f4'>tramadol</span>
products, including ULTRAM ER, particularly with
concomitant use of serotonergic drugs such as SSRIs, SNRIs, TCAs, MAOIs and
triptans, with drugs which impair metabolism of serotonin (including MAOIs) and
with drugs which impair metabolism of tramadol
CYP3A4 inhibitors). This may occur within the recommended dose.