Simvastatin mechanism of action

Common Questions and Answers about Simvastatin mechanism of action

zocor

since i am on a complex combo made of etv, gcmaf, ntz, heptech supplements, any effect on hbv, hbsag is from the combo and it cannot be determined if from sim, ntz or whatever anyway we can say one thing for sure use of simvastatin 40mg for 1 month had no negative effects, normal alt etc, i will slowly increase to 80mg dose and see if any sides or positive effects i am wating for hbsag quantification, hbvdna and hbvdna genes sequence, any of these tests is very useful to determine effect of t
therapeutic Perspective Several viruses including human CMV have been reported to be sensitive to statin administration [25],[26],[28]–[31]. Although the mechanism of action of most is not known, it has in some cases been correlated with a lower abundance of cholesterol in lipid rafts of cell membranes.
It is unlikely that SIM is working as a polymerase inhibitor, since it does not appear to be structurally related to nucleosides/tides. Thus, the mechanism of anti-HBV action by SIM needs further investigation. Most hepatologists no longer consider statins to have any significant hepatotoxicity (Cohen et al., 2006). Millions of people have taken SIM safely. While there are rare adverse effects, these side-effects are well delineated.
To this end, we analyzed the influence of simvastatin on the cell growth and adhesion of HCC and evaluated the yet poorly characterized mechanism of action of simvastatin in HCC. HepG2 and Huh7 cells were treated with simvastatin (16-64 μM) for different time periods. Cell proliferation using the MTT assay and tumor cell adhesion to endothelial cell monolayers were evaluated.
Studies suggest that the mechanism of action of P. amarus may be related to inhibition of HBV polymerase activity. Thyagarajan and colleagues previously reported that 59% of 37 patients with CHB cleared detectable HBV DNA 2–3 weeks after the end of a 30 day treatment period with P. amarus. [Thyagarajan SP, et al.
i have seen the articles on the replicor and have browsed the net regarding the nature and mechanism of this drug. it is made by sulfurization of the oligonucleotide adenine and cytosine DNA sequence using sulfating agent like the Beaucage reagent or TEDT. i was just wondering maybe we can synthesize this modified variant of DNA by finding a sulfurizing agent. for example any drugs which contain sulfur may do the trick. this was just one of my absurd idea on making this med available.
It is unlikely that SIM is working as a polymerase inhibitor, since it does not appear to be structurally related to nucleosides/tides. Thus, the mechanism of anti-HBV action by SIM needs further investigation. Most hepatologists no longer consider statins to have any significant hepatotoxicity (Cohen et al., 2006). Millions of people have taken SIM safely. While there are rare adverse effects, these side–effects are well delineated.
I'm on intf mono but think i need to add on irbesartan or simvastatin or ezitimibe if it acts as HBV inhibitor. In three of these potential inhibitors, irbesartan has less controversial safety profile although simvastatin has been proven to work... used bu Otan.. I need opinion please. History: e-antigen negative. Been on intf for 5 months. Alt had been high and over 230 before and during treatment.
The exact mechanism of action leading to improved RVR, EVR, and SVR in patients receiving vitamin D is unknown. Vitamin D is metabolized by the liver and converted to 1,25-dihydroxy-vitamin D3, which is the active form of the vitamin[6,7]. Individuals with chronic liver disease may have poor conversion from vitamin D3 or any of its other biologically active metabolites[11]. 1,25 vitamin D3 appears to modulate immunity principally via regulation of T-cell function[25].
i guess it is better to try Myrcludex in the immune clearance phase at this point after your light in to the darkness of Myrcludex way of action i do prefer replicor drug, the only thing i fear is a different effect on hbeag negative since the hbeag guy on the huma trial had no response, do you have any data about this? i guess hbsag might be produced in different sites on hbeag negative and i guess it is better to combo also on rep9ac to prevent hbsag mutants...
Further in vitro experiments showed that nitazoxanide suppressed HBeAg and HBsAg suggesting a mechanism of action that differs from other antiviral drugs. The patient treated with nitazoxanide was HBeAb-positive after 4 weeks of treatment with a 2 log10 reduction of viral load (51,000 copies per mm3 down from 5,250,000 at baseline) and a slight increase in ALT (60 up from 53 at baseline). At weeks 8, 12, 16, 20 and 24, he was HBeAg-negative with undetectable serum HBV DNA and normal ALT.
there are several lines of evidences suggesting that the molecular mechanism of exercise-induced upregulation of vascular eNOS expression are closely related to the changes in fluid shear stress in the vasculature. Exercise increases heart rate, which in turn increases blood flow and vascular shear stress, leading to enhanced NO production".
I never smoked but I chewed anywhere from a can to a can and a half a day. One of my nurses told me that 1 can of chew contained the nicotine equivalent of 4 packs of cigarettes. Not sure if that's accurate but that would put me between 4-6 packs for the last 20 years. The good news is that I've Quit and will not go back. The other risk factor's I'm working on and will be diligent to make changes.
Lisinopril: blood pressure Simvastatin: Poor HDL/LDL ratio (LDL O.K. - HDL way low) Metformin ER: Insulin resistant / diabetic CerefolinNAC: Peripheral neuropathy Ambien: Insomnia Each of these problems probably has multiple contributing factors. I take minimum doses of these meds and overall feel O.K. though definitely not as sharp as I was 10 years ago and more inclined to lay aroumd after a hard day's work. "What a drag it is getting old.
Fusion HBx from HBV integrant in human hepatoma cell line is implicated in the development and progression of hepatocellular carcinoma. R. Muroyama; N. Kato; M. Otsuka; J. Chang; M. Omata View Pres. 819. Mechanism of hepatitis B virus persistence following an acute infection – a study using duck hepatitis B virus of the roles of virus replication and cell turnover.. G. Reaiche; M. Le Mire; W. Mason; A. R. Jilbert View Pres. 832.
The was a study that found out that the concentration of 7-Dehydrocholesterol (precoursor of vit D) in hbv infected hepatocytes is abnormally high. It could well be that infected hepatocytes attract 7-DHC from the blood to the liver and less of it is left in the blood to produce Vit D from the sun. So HBVers just can not make enough of vit D from the sun. Therefore the more infected hepatocytes one has the less vit d is in the body. So hbsag and vit d3 levels are negatevely correlated.
I've the exact same symptoms, 3.5 years running. Mine, too, started while doing frequent lifting while working at a retail location, often with 12 hour shifts, standing on unpadded concrete. I've since had 100% desk jobs with no improvement. Pain isn't really all that big of a deal since it rarely lasts past 30 minutes after I wake up. I'm just sick of the insomnia. I've been to a variety of "care providers." with absolutely no results.
MedHelp Health Answers