Simvastatin mechanism of action
Common Questions and Answers about Simvastatin mechanism of action
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I am not physically restricted - I walk 1 mile or more day and do 10 minutes of other light exercises most days. My BP runs under 120/80 most of the time. I understand carvedilol helps prevent stiffening of the heart muscle and can help restore LV function to some degree. How specially, so it do this? What is the biochemical mechanism?
http://www.visbdev.net/visbdev/fe/Docs/drug.
The serum levels of C-reactive protein (CRP) were significantly reduced by simvastatin. The proportions of CD4+ and CD8+ T cell subsets expressing early (CD25) or late (HLA-DR) activation markers, as assessed by flow cytometry, were not changed by simvastatin. However, simvastatin tended to increase the density of HLA-DR and L-selectin per CD8+ T cell. The T helper(h)1/Th2 response was evaluated by stimulatory assays followed by intra-cellular staining of interferon-γ and interleukin-4.
The mechanism of action of Campral® (acamprosate calcium) Delayed-Release Tablets in maintenance of alcohol abstinence is not completely understood. Originally, several neurotransmitter systems, including GABA, were investigated for a possible role in Campral's mechanism of action. However, recent evidence suggests Campral's main interaction is with the glutamate system. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition.
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Plavix has a unique mechanism of action by blocking the amplification of platelet activation by released ADP, and often used with aspirin to prevent the risk of clots for the first year after DES implant. Plavix and aspirin have different mechanism of action to prevent clots. After a year, plavix is usually discontinue as the risk for clots is decreased, and aspirin is continued long term. The risk of a clot is about 3%.
When I went back to my doctor I found out that I had an 80% blockage of my LAD. I am on Plavix, metoprolol, losartan and simvastatin along with insulin for my sugar. I also have severe pain in my arms, hands, neck and head which is why I did not recognize the symptoms of the first heart attack. My question is if I will be okay without any further intervention with the 80% blockage as long as I am on the medicine? My doctor did not seem to want to place the stent in the LAD.
therapeutic Perspective
Several viruses including human CMV have been reported to be sensitive to statin administration [25],[26],[28]–[31]. Although the mechanism of action of most is not known, it has in some cases been correlated with a lower abundance of cholesterol in lipid rafts of cell membranes.
HIV is transmitted by;
Unprotected penetrative anal and/or vaginal sex
Sharing works with other IV drug users
Mother to child
You never had an exposure.
If you feel it is the Simvastatin, you can always ask your doctor about going off of it for a short while to see if it improves. This is a rare side effect of Simvastatin so I would look elsewhere for the problem. You should speak to your doctor.
The only negative I have read about Simvastatin in recent times is a study that showed high doses of simvastatin of 80 mg puts a patient at a greater risk for side effects including muscle damage. Most doctors have backed off of the 80 mg dosage as a result. I have been on 40 mg for years and it has worked great for me with no issues.
Your husband needs to address this concern with his doctor. He needs to understand why there was a change in treatment.
i dont understand cholesterol issues,but anyways one of my numbers was low(im thinking good cholesterol)not sure though it was 35...one was ok...maybe it was the combination but he put me on simvastatin..im scared to take it.im on meds for thyroid and hormones,plus on a antibotic right now.......can any one tell me anything about this med?
It is hard to say. If you still have symptoms of a cold a cold doesn't usually make you achy. If you had a fever with the so called cold maybe it was really the flu. Flu season has started in some states at low levels. But, it could be the drug. If it is it won't pass and you would have to get off of it. I would either call your doctor or wait a couple of weeks. If it doesn't go away it is the drug. You don't want to wait too long.
Due to the potential for severe interaction, concomitant use of atorvastatin, lovastatin, or simvastatin with telaprevir is considered contraindicated. Red yeast rice, which contains lovastatin, should also be avoided during treatment with telaprevir. Fluvastatin, pravastatin, pitavastatin, and rosuvastatin are probably safer alternatives, since they are not metabolized by CYP450 3A4.
curious if stef2011 or studyforhope or StephenCastlecrag know whether simvastatin by itself can reduce viral load? I've read about the effects in conjunction with NUCS but I'm curious if sim is effective alone.
I am a 62 year-old male who has been taking simvastatin for about 30 years. All of my cholesterol-related numbers are in a healthy range, and I have never experienced any serious side effects (e.g., muscle weakness, kidney and liver impairment, etc.). I have, however, had trouble sleeping for the past several years (perhaps caused by simvastatin, perhaps not). More importantly, I have been experiencing back pain for the past few months and would like to try CBD.
Potassium is a chemical element and it is part of the electrolyte that should be in balance with other lytes to adequately conduct an electrical impulse that originates with the sinus node in the right atrium. The mechanism of action is not completely understood, but what is when a voltage (unit of potential for conduction) and electrolyte there will conduction and passage of electrical impluses.
Your symptoms could mean rhabdomyelosis, which is very serious. Have you tried lowering your cholesterol by natural means?
My endocrinologist prescribed me Atorvastatin 40mg in place of the simvastatin but it has since given my major chest pain and muscle weakness in my fingers and legs; so I was advised by the pharmacist to stop that and I have only taken the new statin twice and tonight was the second time taking it.
Is simvastatin something that can be eased up to a higher dose to do the exact same thing atorvastatin does for the bad cholesterol?
I was told I have mild left ventricular hypertrophy and left atrial enlargement. I am very overweight with a bmi of 41, male, 33 years old, and a smoker (trying to quit). I was put on metoprolol200 mg per day, amlodipine 10 mg, and since my high sensitivity c-reactive protein was 8.9, I was put on simvastatin 5mg. The medicine was controlling my blood pressure over the last couple of months but now it is not. I consistently run in the 150/95 range. My resting heart rate stays around 90.
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