The decrease in hepatic fibrosis was associated with a reduced collagen-1, TGFβ, NFкB
mRNA expression and desmin and α-SMA
protein expression.
Conclusions
Resveratrol administration reduces portal pressure, hepatic stellate cell activation and liver fibrosis, and improves hepatic endothelial dysfunction in cirrhotic rats, suggesting it may be a useful dietary supplement in the treatment of portal hypertension in patients with cirrhosis.