10,11,13,14,17,18,43 For example, in patients with moderate to
severe liver dIs
ease, peak plasma levels of <span style = 'background-color: #dae8f4'>Oxycodone</span>
and its chief metabolite norOxycodone
were increased 50% and 20%, respectively, whereas the area under the plasma concentration-time curve for these molecules increased 95% and 65%.11 Peak plasma concentrations of another active metabolite, Oxymorphone
, were decreased by 30% and 40%, respectively....