However, if the fissures do not heal with these remedies or persists after 6 weeks, further evaluation by your doctor and additional treatment are indicated. Nitroglycerin
cream can reduce the pressure in the internal anal muscle and allow the fissure
to heal. Use it as prescribed by your doctor since this can cause side effects such as headaches, lightheadedness, or fainting from low blood pressure. Try to wear gloves when applying the nitroglycerin cream or wash your hands right after.