By contrast, slow-release
niacin preparations reduce the hot-flush effect by releasing
niacin over an extended period of 12 hours or longer. Most of these preparations are unsafe and I do not recommend them. “No-flush” niacin preparations, such as inositol hexaniacinate and nicotinamide, are widely sold as niacin alternatives that do not cause hot flushes. In my experience, however, they simply do not work. In other words, no flush, no effect.