Not enough and skin can become suspectible to bacterial and fungal infections under
the influence of immune suppressing drugs. Perhaps it's conincdence, but several skin on tx flared including Seborrheic Dermatitis, which may be fungal in nature. It appeared near the sabaceous glands -- face, scalp, chest, armpits, groin, etc. Treatment is topical antifungal meds, medicated talc and possible some cortisone intially for inflammation.