Yes, the prophylactic administration of isoniazid (INH) for a TB chest
conversion may cause inflammation
of the liver, but does so in a minority
of individuals taking the medicine. However, there is also the risk of liver inflammation due to the medicine Crestor® (rosuvastatin) and it is conceivable that there could be an additive effect of Crestor® (rosuvastatin) and INH. In addition, niacin may increase the risk of muscle disease called myopathy when used with Crestor® (rosuvastatin).