yup, it is 100% safe to take during pregnancy. And it's a godsend of a medication lol. I had a double ear infection, double sinus infection, and stage 1 phumonia(sp), and Zithromax had me cleared up and feeling better withen the same night of taking it. I was also worried to take it at first, so I called almost every pharmacy in town and asked about it, and I got the same answer, which is it's safe, and I even called my doc and double checked with him lmao.