Crestor is a statin (rosuvastatin calcium) only, Vytorin is a statin (Simvastatin) with Zetia (ezetimibe). Statins work by controlling the production of cholesterol in your liver while Zetia works by preventing cholesterol to be absorbed in your digestive system.
Of the two, Crestor is the stronger of the two. In addition, recent trials have shown that adding Zetia does not improve the performance of Vytorin over Simvastatin alone.
Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (about one case for every 15 million prescriptions). Rhabdomyolysis can cause liver damage, kidney failure and death. Rhabdomyolysis can occur when statins are used in combination with certain other drugs.
Liver damage Occasionally, statin use could cause your liver to increase its production of enzymes. If the increase is only mild, you can continue to take the drug.
I am presently taking Zetia every other day. I also take Omega 3/6, vitamin A,E. With Zetia interfere with the absorption of the benefits of these supplements and if so what can I do to get the full benefit of Zetia and the supplements, if anything.
Ar there any other supplements that should be avoided while taking Zetia?
Many thanks.
What will happen if an athlete with Rhabdomyolysis continues to play his sport? What will happen in the long run?
At that point, our doctor added 10 mg Zetia to his regimen because of elevated LDL particles. Also, my husband stopped all alcohol (he was a social drinker, around 2-3 glasses of wine per week) and NSAID's. A month later most of his LFT's were elevated, ALT 79, GGTP 178, ALP 113 & AST on upper end of normal at 40. The doctor said to stop the Lipitor...but stay on the Zetia...... and retest in 1-1/2 weeks which he did this past Sept. 30th.
Since you know your CK levels, I assume you've seen a doctor about this? Do you have other symptoms, like muscle tenderness, nausea, etc?
In any case, high CK and dark urine are among the signs of rhabdomyolysis (google it), which is not a Good Thing. It's a breakdown of skeletal muscle. It can be caused by too- vigorous exercise, especially when dehydrated, among other things.
I have been having some highCholesterol level for 3 years now. I was on medication in and out as I develop side effects to the statin drugs. I was on Lipitor, then on Pravachol and lastly on Crestor. None of them had problems loweting the Choesterol levels, but muscle and joint pain even with Vit D and Co Q10 as prescribed my physician. However, I came off crestor yesterday as I started feeling Dizzy. I am normally a "healthy", active energetic person.
Incidentally, unrelated to GA, I started taking Zetia for cholesterol about 3 years ago and soon thereafter developed a severe chronic cough that nearly drove me crazy (and everyone around me!) I saw several doctors and was given many different medicines.
Can anyone explain to me why I still had a heart attack even while taking the following meds atenenol 50mg bid, HCTZ 25mg daily, zetia 40mg daily, plavix 25mg daily, welchol 625mg bid. Also what is the chance of a second heart attack
My Aortic Valve, Tricuspid Valve, and my Mitral Valve are failing because they are stenotic and regurgitative. The Aortic valve is in the worst shape of the three they tell me. I have psoriatic arthritis and ankolosing spondylitis. all joints are involved.
Ever since I started taking Zetia and Fenofibrate together as recommended by my DR, I have put on pounds, am more bloated around the belly,a nd have persistent chest pains. I noticed this has occurred ever since I have been on cholesterol lowering meds, but is more noticeable in the past year with the new combination of drugs. I mentioned this to my DR and he said I need the drugs because of my High Cholesterol. What do you think?
This intense pain is a symptom of rhabdomyolysis,a rare condition that causes muscle cells to break down. This does not make your muscle tissue "mushy", it just causes cells t breakdown.
The most common signs and symptoms of rhabdomyolysis include:
* Severe muscle aching throughout the entire body
* Muscle weakness
* Dark or cola-colored urine
These symptoms usually occur in the first 90 days of treatment and happen in less than 1% of those taking Lipitor.
Statins work in the liver and every commercial I have seen advises not to take if you have liver problems. Zetia works in the intestines.
Was the Zetia working?
If my memory serves me correctly, MikeS is taking statins and he had a TP. He is far more knowledgeable on the subject than I am and hopefully he will see this post and give his input.
Zetia is part of a class of drugs called cholesterol absorption inhibitors.
Anyone here know anything about zetia and its affect on the thyroid and or levo absorption? I have read it may affect absorption and the rx monograph says talk tp your doctor if you have thyroid disorders.
He knows I am on synthroid, but I am curious how this drug affects it.
Rhabdomyolysis is a life-threatening condition that results from myositis, a condition which destroys muscle cells causing pain, particularly in the calves and lower back. The condition can become so severe that it leads to kidney failure. Symptoms of rhabdomyolysis include, but may not be limited to, muscle pain, weakness, tenderness, fever, dark urine, nausea, and vomiting.
MB bands which are Cardiac Bands and MM bands which are muscle bands. Weight lifters or people with rhabdomyolysis can knock the MM bands way out of whack. Muscle breakdown will throw the MM band quite high.
About 4 years ago, I was overworked by a personal trainer in the gym and ended up in the hospital for 5 days due to Rhabdomyolysis. I had never heard of this disease before this day. Turns out the trainer overworked me. Needless to say, I am not a big fan of exercise since then. I've dabbled with it over the past few years.
With numbers as high as yours, you need some medical interaction as lifestyle changes alone will not get your levels low enough to be healthy. You could try getting some exercise, but I doubt if that alone would do it, even with a healthy diet. It is unfortunate that you are in the small minority of people (approx 1% of users) that have adverse side effects from statin use, but not all statins are the same.
t find the right medicine...Lipitor caused severe muscle weakness, Zetia caused all kind of digestive problems and Pravachol zapped my energy...my count actually went up 30 points while taking WelChol! My doctor is telling me that I have no other choices of medicine to lower my count (total 285, HDL 106 VLDL 21, LDL 188, Triglycerids 106.) My sister is having the same problem so I guess this problem is a family thing. I am really troubled by my doctor's lack of concern.
also be aware that the big decline will be at 48-72 weeks with your hbv mutations and hbeag negative
the difference of fibroscan between 4 and 6 is meanless, you have nothing to worry
you may try to see if intf response can be increased by ezetimibe (zetia) or smvastatin.
Did your doctor prescribe 2,000 per day and is that what you took? Your post is also not clear when you say consecutive 3-4 dosing at 2,000.
Rhabdomyolysis, kidney problems so that I ultimately had to stop them, but knee burning/pain while walking wasn't one of them.
Those tests showed that my CPK levels exceeded 135,000 and i was diagnosed with Rhabdomyolysis. All other tests did not reveal the cause of the Rhabdomyolysis but no-one at the hospital seemed to have ever heard of cpk levels this high. My searches on the internet have also not revealed any levels nearing this. I am now down to 4000 (and hopefully dropping).
any thoughts?
have there been other cases with cpk levels exceeding 135,000 and what was the cause?
The earlier mentioned side effect caused by the group of medications known as the statins, which Vytorin (ezetimibe/simvastatin) is a member of, is called rhabdomyolysis. This condition is breakdown of the muscle and has been associated with the statins as a class as a rare but serious side effect. Rhabdomyolysis caused by statins is reversible once the medication has been discontinued.
It can potentially be an early indicator of a very serious condition called rhabdomyolysis that can be a side effect. Dark urine can also accompany rhabdomyolysis. From what I see on line, creatinine kinase is what your doctor should have tested and if it is elevated, the drug should be discontinued.
How are you? Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required. The normal ranges of GFR, adjusted for body surface area for males is 70 ± 14 mL/min/m2 (56-84) . Risk factors for kidney disease include diabetes, high blood pressure, family history and older age.
Take care and keep us posted.
Recommended
