Hello,
Statins are known to have the adverse effect of liver enzyme elevation, which is generally asymptomatic. Severe liver damage as a result of statin is virtually unknown. The current clinical practice is to discontinue statin when the liver enzymes have increased to more than three times the upper limit of normal. Although zetia on its own does not generally cause liver enzyme abnormalities, it might potentiate the enzyme abnormalities, when coadministered with a statin.
Statins work in the liver and every commercial I have seen advises not to take if you have liver problems. Zetia works in the intestines.
Was the Zetia working?
If my memory serves me correctly, MikeS is taking statins and he had a TP. He is far more knowledgeable on the subject than I am and hopefully he will see this post and give his input.
Zetia is part of a class of drugs called cholesterol absorption inhibitors.
Statins work by controlling the production of cholesterol in your liver while Zetia works by preventing cholesterol to be absorbed in your digestive system.
Of the two, Crestor is the stronger of the two. In addition, recent trials have shown that adding Zetia does not improve the performance of Vytorin over Simvastatin alone.
The Fenofibrate can cause bloating indigestion, stomach pain, and increased liver enzymes or liver problems in addition to other side effects. The Zetia can cause some of these too. Have they tested your liver enzymes yet? If so were they normal? There are other drugs for lowering cholesterol and triglycerides that work as well. You can ask him to have you try Lipitor (generic) and there is now a generic Niaspan. I know because my husband is on it.
I am presently taking Zetia every other day. I also take Omega 3/6, vitamin A,E. With Zetia interfere with the absorption of the benefits of these supplements and if so what can I do to get the full benefit of Zetia and the supplements, if anything.
Ar there any other supplements that should be avoided while taking Zetia?
Many thanks.
The pravastatin could be the reason, however which of his liver enzymes are elevated? Let us know and I may be able to help you out.
I am 48 year old female, have had high cholestrol for which I have been on Zetia & Tricor for several years, now is almost normal. I had a bad reaction to the statins- ended up in the hospital with very high liver enzymes. Recently, I have been getting very lightheaded and experiencing pain in my upper arms. My doctor refered me to a cardiologist who performed the heart ultrasound and the holter which came back normal.
I have been having some highCholesterol level for 3 years now. I was on medication in and out as I develop side effects to the statin drugs. I was on Lipitor, then on Pravachol and lastly on Crestor. None of them had problems loweting the Choesterol levels, but muscle and joint pain even with Vit D and Co Q10 as prescribed my physician. However, I came off crestor yesterday as I started feeling Dizzy. I am normally a "healthy", active energetic person.
Incidentally, unrelated to GA, I started taking Zetia for cholesterol about 3 years ago and soon thereafter developed a severe chronic cough that nearly drove me crazy (and everyone around me!) I saw several doctors and was given many different medicines.
With numbers as high as yours, you need some medical interaction as lifestyle changes alone will not get your levels low enough to be healthy. You could try getting some exercise, but I doubt if that alone would do it, even with a healthy diet. It is unfortunate that you are in the small minority of people (approx 1% of users) that have adverse side effects from statin use, but not all statins are the same.
Can anyone explain to me why I still had a heart attack even while taking the following meds atenenol 50mg bid, HCTZ 25mg daily, zetia 40mg daily, plavix 25mg daily, welchol 625mg bid. Also what is the chance of a second heart attack
My Aortic Valve, Tricuspid Valve, and my Mitral Valve are failing because they are stenotic and regurgitative. The Aortic valve is in the worst shape of the three they tell me. I have psoriatic arthritis and ankolosing spondylitis. all joints are involved.
Diffuse fatty infiltration of the liver w/o definite focal liver lesion. No focal lesions in the spleen, gallblader, addrenal glands, pancreas or kidneys. No renal, ureteral or bladder calculi. No hydornefrosis. The right kidney is somewhat malrotated.
No abdominal or pelvic lymphadenopathy. The bowel is not dilated. The appendix is unremarkable. Prostate gland is not enlarged. No suspicious osseous lesions.
Anyone here know anything about zetia and its affect on the thyroid and or levo absorption? I have read it may affect absorption and the rx monograph says talk tp your doctor if you have thyroid disorders.
He knows I am on synthroid, but I am curious how this drug affects it.
I agree, each to their own but I will stick with coffee, dark and strong.
There are all kinds of statins out there, as ed said, you have to find out which one you tolerate. I have been on them for many years as I was unable to lower my LDL with diet and exercise alone. They have worked well and I have had no side effects, but everyone is different. Most of these can be replaced by the generic Simvastatin. It's cheap and is the basis of many of the meds out there.
These medicines bind to bile, so it cannot be used during the digestive process. Your liver responds by making more bile. The more bile your liver makes, the more cholesterol it uses. So, less cholesterol is left to circulate through your bloodstream.
•Nicotinic Acid (Brand names: Niacor, Nicolar, Slo-Niacin)
Nicotinic acid, or niacin, is a form of vitamin B. It appears to slow the liver's production of certain chemicals that help to make LDL ("bad") cholesterol.
t find the right medicine...Lipitor caused severe muscle weakness, Zetia caused all kind of digestive problems and Pravachol zapped my energy...my count actually went up 30 points while taking WelChol! My doctor is telling me that I have no other choices of medicine to lower my count (total 285, HDL 106 VLDL 21, LDL 188, Triglycerids 106.) My sister is having the same problem so I guess this problem is a family thing. I am really troubled by my doctor's lack of concern.
Thx. Mike:
Along the same lines I had read this and I remember seeing at one time about the regulators here in Can. reporting on it.
Yes... a little confusing on what exactly caused what ,however possibly because of the conflicting info. it has been put aside as an adjunct to HCV therapy.
Will
Regulators in Australia and Canada have warned since 2005 about the drug's potential to cause hepatitis, pancreatitis and depression.
also be aware that the big decline will be at 48-72 weeks with your hbv mutations and hbeag negative
the difference of fibroscan between 4 and 6 is meanless, you have nothing to worry
you may try to see if intf response can be increased by ezetimibe (zetia) or smvastatin.
How are you? Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required. The normal ranges of GFR, adjusted for body surface area for males is 70 ± 14 mL/min/m2 (56-84) . Risk factors for kidney disease include diabetes, high blood pressure, family history and older age.
Take care and keep us posted.
After electrograms, changes in cholestrol medication,( lipitor, crestor,), now on zetia my tests keep coming in high.Outside of my lower extremities aches, which I credit to arthritis, I feel fine. Both doctors, arthritis and cardiologist, keep drawing blood with these rates still climbing. After a year of this circle, and being a believer in preventive mediciene, my concern is should I be concerne?
Diet only lowers your cholesterol by about 10%. So, it helps to not eat any extra cholestrol as your liver is what genetically controls the amount of receptors you are born with that break down cholesterol. So, try not eating anything with partially hydrogenated fat (trans fat), none. Also, have no egg yolks, no bacon, and so forth. Eat whole wheat cereal with fruit for breakfast, non fat milk or vanilla soy milk. lots of vegies and fruits etc. Very light on meats.
Diffuse fatty infiltration of the liver w/o definite focal liver lesion. No focal lesions in the spleen, gallblader, addrenal glands, pancreas or kidneys. No renal, ureteral or bladder calculi. No hydornefrosis. The right kidney is somewhat malrotated.
No abdominal or pelvic lymphadenopathy. The bowel is not dilated. The appendix is unremarkable. Prostate gland is not enlarged. No suspicious osseous lesions.
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