Statins work in the liver and every commercial I have seen advises not to take if you have liver problems. Zetia works in the intestines.
Was the Zetia working?
If my memory serves me correctly, MikeS is taking statins and he had a TP. He is far more knowledgeable on the subject than I am and hopefully he will see this post and give his input.
Zetia is part of a class of drugs called cholesterol absorption inhibitors.
Statins work by controlling the production of cholesterol in your liver while Zetia works by preventing cholesterol to be absorbed in your digestive system.
Of the two, Crestor is the stronger of the two. In addition, recent trials have shown that adding Zetia does not improve the performance of Vytorin over Simvastatin alone.
Hello,
Statins are known to have the adverse effect of liver enzyme elevation, which is generally asymptomatic. Severe liver damage as a result of statin is virtually unknown. The current clinical practice is to discontinue statin when the liver enzymes have increased to more than three times the upper limit of normal. Although zetia on its own does not generally cause liver enzyme abnormalities, it might potentiate the enzyme abnormalities, when coadministered with a statin.
The Fenofibrate can cause bloating indigestion, stomach pain, and increased liver enzymes or liver problems in addition to other side effects. The Zetia can cause some of these too. Have they tested your liver enzymes yet? If so were they normal? There are other drugs for lowering cholesterol and triglycerides that work as well. You can ask him to have you try Lipitor (generic) and there is now a generic Niaspan. I know because my husband is on it.
Fat-soluble statins like Lipitor and Zocor cause more damage than water soluble statins like Pravachol and Crestor. Hence the latter should be tried at lower dose. Possibility of hypothyroidism and diabetes should be ruled out as the presence of either disease can complicate the muscle pain. Please discuss these points with your treating physician. It is difficult to comment beyond this at this stage.
Hope this helps. Please let me know if there is any thing else and do keep me posted.
potential to increase liver enzymes and cause liver damage, patients must be monitored for normal liver function. At least, that's what the label used to say. Now the FDA has removed this long-standing warning and ruled that patients taking statins no longer need routine monitoring of liver enzymes, but instead can have liver enzymes tested before starting the drugs, and then only as clinically needed.
If it were me I would give pravastatin a chance, but if I had the same side effects and I could not live with them, I would try something like Zetia. You could also add a fenofibrate like Tricor to lower your TGLs as well, very safe and no side effects. This will help lower your overall number but will not impact your LDL which is you main issue. You really need to get that under 130 with no other risk factors.
The pravastatin could be the reason, however which of his liver enzymes are elevated? Let us know and I may be able to help you out.
Although there have been reports of liver failure and hepatitis associated with statins and elevated liver enzymes, these occurrences are rare. Current studies have not been able to establish a definite link between statin use and liver disease. If for some reason your liver enzymes do become elevated, they are restored back to normal once the statin is stopped.
I think it's more of which one your body will tolerate the best. Different brands seem to show different side effects in many people. Lipitor in some women have produced breast pains or enlargement and even the manufacturers cannot explain that one. Still, I suppose it's cheaper than plastic surgery. Some statins cause abdominal pains in some people, or nausea or serious muscle cramps and even damage.
After electrograms, changes in cholestrol medication,( lipitor, crestor,), now on zetia my tests keep coming in high.Outside of my lower extremities aches, which I credit to arthritis, I feel fine. Both doctors, arthritis and cardiologist, keep drawing blood with these rates still climbing. After a year of this circle, and being a believer in preventive mediciene, my concern is should I be concerne?
People can have elavated readings but have little or no damage and you can have normal readings but have damage.
s cholesterol medication Zetia, when combined with statin drugs might cause damage to the liver, and that this risk had not been revealed by the companies. The discovery of the unpublished research adds more fuel to the controversy involved in the failure of Schering and Merck to make a timely disclosure of the results of the Enhance study that we discuss in the items below.
A Schering executive, Dr. Robert J. Spiegel, when queried about the unpublished studies confirmed their existence. Dr.
I had a bad reaction to the statins- ended up in the hospital with very high liver enzymes. Recently, I have been getting very lightheaded and experiencing pain in my upper arms. My doctor refered me to a cardiologist who performed the heart ultrasound and the holter which came back normal. The stress test however was abnormal- 1 millimeter st segment depression. My cardiologist would like to a heart cathetrization and possibly insert stents.
I have had normal liver enzyme test and a normal ultrasound and ct scan, but I still have extreme bloating. This has been going on for months now. I worry because I binge drank on a nightly basis for about an 8 year span, 3-5(sometimes more) glasses of wine and such. Should I be worried that I have liver damage that is just not showing up? I have changed my diet significantly ( no dairy or gluten) but I am still very bloated. I am sick with worry that I have caused permanent damage.
The only way to truly ease your mind is by being totally honest with him/her. I have liver damage and kidney damage due to drugs stage 2 liver stage 3 kidney.. if your liver were damaged and you had a flare your belly would be extended/pain upper right you would be lethargic/vomiting.. other symptoms but these being severe.. It is not fun and I would not wish it on anyone.. I contracted hep C from slamming and further continued the damage through pills/alcohol..
no telling and best to see ur doctor and have it checked...if liver damage is worrying u from massive tylenol use..get the doc to draw ur liver enzymes to know for sure ur liver is ok....the liver is amazing at adjusting/the whole body is/to abuse...I have often thought i had a liver made of concrete with the massive tylenol i ingested...
for a checkup yesterday and the ALT liver function test was high. The other liver tests were normal just that one was high. The Dr. thinks it is from my acid reflux medication and is changing that but I rarely take it. Could it be the Darvocet? Sometimes I take one then another before the four hours are up for the next dose but mostly only one at a time. I just thought as long as I only took the recommended amount I wouldn't damage my liver.
I have been taking 3 to 4 vics a day. They are 10mg-660's. I don't drink, am I trashing my liver?? Please help, I'm stressin....because I have a mild pain that comes and goes in my upper right quadrant of my abdomin. I had blood work done 6 months ago and all liver panels were good. Had an ultrasound done as well and that came back perfect. What's going on here?
Recommended
