Fat-soluble statins like Lipitor and Zocor cause more damage than water soluble statins like Pravachol and Crestor. Hence the latter should be tried at lower dose. Possibility of hypothyroidism and diabetes should be ruled out as the presence of either disease can complicate the muscle pain. Please discuss these points with your treating physician. It is difficult to comment beyond this at this stage.
Hope this helps. Please let me know if there is any thing else and do keep me posted.
t find the right medicine...Lipitor caused severe muscle weakness, Zetia caused all kind of digestive problems and Pravachol zapped my energy...my count actually went up 30 points while taking WelChol! My doctor is telling me that I have no other choices of medicine to lower my count (total 285, HDL 106 VLDL 21, LDL 188, Triglycerids 106.) My sister is having the same problem so I guess this problem is a family thing. I am really troubled by my doctor's lack of concern.
After electrograms, changes in cholestrol medication,( lipitor, crestor,), now on zetia my tests keep coming in high.Outside of my lower extremities aches, which I credit to arthritis, I feel fine. Both doctors, arthritis and cardiologist, keep drawing blood with these rates still climbing. After a year of this circle, and being a believer in preventive mediciene, my concern is should I be concerne?
Remember, your statin has a half life of about 14 hours which means after 14 hours you have eliminated half of the medication. You will then eliminate half of the remaining have after the next 14 hours and so on and so on.
I took niacin for 20 yrs. I am now 67 and have tried two different popular statins( lipitor and crestor which did lower LDL about 50 pts but also lowered HDL). I could not tolerate either statin because of personality changes ie: anger and irritability all the time and severe cognitive issues with memory, reasoning and being able to focus. After stopping each statin, it has taken me longer to get back to normal mentally.
My understanding is that the statins with the greatest LDL reducing effect are Crestor, Lipitor, Zocor, and Pravachol, in that order. I don’t mention Leschol and Mevacor since they appear to be rarely used since recently due to the aforementioned being more powerful. Do we have any available solid data on the effects of the various individual statins other than LDL reduction? For example, do we know which ones raise HDL the most? What about effects on particle size or Lp(a), etc.
t have good effects to prevent heart attacks. Howeverk, Crestor was shown to reduce plaque and had better results in clinical studies. Also, with the Niaspan, it is known to raise HDL level but HDL is not necessarily protective as they thought. But that study may be skewed because it was done on all cardiac patients.You may want to read about Vytorin there was a problem with it and I can't remember all the details.
Ever since I started taking Zetia and Fenofibrate together as recommended by my DR, I have put on pounds, am more bloated around the belly,a nd have persistent chest pains. I noticed this has occurred ever since I have been on cholesterol lowering meds, but is more noticeable in the past year with the new combination of drugs. I mentioned this to my DR and he said I need the drugs because of my High Cholesterol. What do you think?
I recently had a heart cath and stent placement (5 in the RCA and 2 in the OM2). After the stenting I was prescribed the following medications: Effient-10mg, Zestril-2.5mg bid, Zetia-10mg, Lovaza-2g bid, along with those I already take which are: Toprol XL-50mg, Crestor-40mg, Zantac-150mg, and Aspirin-325mg.
Now, it's been almost a week since my procedure and beginning the new meds.
Statins work in the liver and every commercial I have seen advises not to take if you have liver problems. Zetia works in the intestines.
Was the Zetia working?
If my memory serves me correctly, MikeS is taking statins and he had a TP. He is far more knowledgeable on the subject than I am and hopefully he will see this post and give his input.
Zetia is part of a class of drugs called cholesterol absorption inhibitors.
AST on upper end of normal at 40. The doctor said to stop the Lipitor...but stay on the Zetia...... and retest in 1-1/2 weeks which he did this past Sept. 30th. His ALP came down to normal at 91, his ALT stayed the same at 79, his AST stayed relatively the same at 42, but his GGTP went quite high at 240. The doctor's office called and told him to come in next week.
After 7 years of therapy taking Crestor and Tricor (fenofibrate), I, too, started experiencing intense pain in my legs, feet, back, and arms. My Dr. took me off Crestor last month but the pain returned within a few days, although not as intense as it was prior to my stopping Crestor. I took myself off fenofibrate just a couple of days ago and "Wow" what a difference! I can actually sleep at night and notice that the pain is dissipating more and more each day.
I started on crestor, than realized I am ttc and starting not feeling well and am on my ttw...I test for my pregnancy saturday. I took the crestor for 4 days than stopped and its been a little over a week. Should I restart and then stop if pregnant or not bother because of the possibility of there being a fetus?
I am just worried about my health.
The weakness and aching are signs of rhabdomyalgia which is a side affect of statin drugs. You need to see the doctor that prescribed the meds as he/she needs to check you. I don't know about the shortness of breath. It could be a drug reaction too.
I finally went to a specialist in Baltimore who read my history which showed all the meds I was taking and he noticed that I was taking Zetia and told me that he believed Zetia caused chronic coughing in some people; so he looked it up on his computer and sure enough, that was one of the warnings. I stopped the Zetia and the coughing disappeared completely within a couple of weeks. The point here is that medicines, while helping one problem, frequently can cause another.
Has anyone gotten worsening of their PVC's from taking a statin drug? I seem to be intolerant of these drugs and have tried Crestor, Lipitor and Lescol. My PVC's go absolutely nuts when I take them. I have done my own tests by going off and on them. I consistently get worse when I'm on them. I take C0Q10 and a whole bunch of supplements including magnesium to no avail. Any feedback would be appreciated.
I just got off of zetia and welchol. I could not take statins. I tried them all. Used to take Niaspan and fenofibrate but they took me off cause both cause problems in some and had not 'reduced the incidence of cardiac events'. I think they have concluded that neither do Zetia, except when used with a statin, so it is the statin doing the work. I also think Welchol has been shown to not reduce cardiac events too. not sure. I am on Repatha. Third bi weekly shot.
Had been on Augmentin for a sinus infection, just finishing up the script, and take Crestor, Nexium, and Zyrtec on a regular basis. Symptoms started a few days after starting generic Zyrtec, which also caused unbelievable dryness that felt like I was dehydrated (no vomiting, though). A day after the chills, I noticed my urine was dark and my stools were very light, almost gray, and I started getting very itchy but no rash.
However, there is also the risk of liver inflammation due to the medicine Crestor® (rosuvastatin) and it is conceivable that there could be an additive effect of Crestor® (rosuvastatin) and INH. In addition, niacin may increase the risk of muscle disease called myopathy when used with Crestor® (rosuvastatin). Crestor® (rosuvastatin) significantly increases the INR (enhances the effect of Coumadin to make your blood “thinner” than it would be alone.
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