Your 63 year-old wife has a several year history of heart arrhythmias, rapid heart rate, heat intolerance, and
weight loss with repeatedly normal thyroid results. The third-generation TSH assays that are used these days are highly sensitive, so yes, the tests would have more than likely picked up on a thyroid abnormality. Bulging eyes, an enlarged thyroid (goiter), non-pitting edema of the extremities are other clues that would make your doctor suspect Grave’s hyperthyroidism.