A detailed analysis of the relationship between body weight and SVR has suggested that the dose per kilogram is the determining factor of response in genotype 1 patients, based on the 40% to 50% rise in SVR for a 12-16-mg/
kg increase in RBV dose (23). RBV dose by
weight may impact its concentration in plasma, which also correlates with the response. Although this relationship has been well documented in genotype 1 patients, the data are less clear for other genotypes.