5, but when APAP was stopped his
INR dropped to 1.62. Two weeks later, he restarted APAP
and the
INR climbed to 2.0 over 4 weeks (5). A 77-year-old woman who developed a 2-fold increase in INR while receiving APAP with concomitant acenocoumarol (8), and a 74-year-old man experienced a 3-fold increase in INR when APAP was added to his stable warfarin regimen (6). Fluindione has also been implicated in this interaction (9).