Edema can occur on the basis of heart disease, liver disease, kidney disease, and chronic venous insufficiency, with or without
deep vein
thrombosis. The
venous insufficiency can be aggravated by obesity
and sitting for long stretches of time, relatively immobile with your feet on the floor. However, the symptoms you describe, “chronic atypical chest tightness, and during certain times, shortness on breath and quick fatigue even with slight exertion.