s why they do the trials. However, the drugs
generally outperform placebo by enough of
a percentage to get approval, and placebo effects generally wear off while drugs keep working. Some people also get worse side effects from placebo than from the real drug, just showing how complex the human brain is. Opiates would be a bad choice for depression, as they cause depression in many people because they're a downer drug. Benzos can do the same thing if you take them too often.