ANA tests can be false-positive in many conditions, including rheumatoid arthritis, subacute bacterial endocarditis, human immunodeficiency virus infection, liver disease, malignancy, type 1 diabetes
, pulmonary fibrosis and multiple sclerosis. False-positive tests also occur in patients with silicone gel implants, pregnant women and the elderly.9
When an ANA test is positive, the nuclear staining pattern is frequently reported. This pattern reflects the intracellular target of ANA.