Hi!
Generally a high ANA titre indicates an autoimmune disease (SLE, Sjögren's syndrome, rheumatoid arthritis, autoimmune hepatitis, scleroderma, polymyositis, autoimmune hemolytic anemia, dermatomyositis, primary biliary cirrhosis, Addison disease, Idiopathic thrombocytopenic purpura (ITP), Hashimoto's Thyroiditis, and type 1 diabetes mellitus). Mixed connective tissue disorders also cause a high ANA. What is important is the pattern of ANA staining: homogenous, speckled, or nucleolar.