Tri-Sprintec typically causes nausea, bloating, stomach cramps, breast pain, vaginal discharge, menstrual irregularities
and changes in your appetite
and weight.
Tri-Sprintec can affect your appearance and cause increased hair growth, loss of hair or freckling of your skin. It can cause nervousness, a headache and fatigue. These side effects are fortunately rather benign. However, they may become bothersome if they last for more than three days.