s), including amitriptyline and doxepin, are effective in
treating multiple FM symptoms including
pain, sleep disturbance, fatigue, and depression. Serotonin re-uptake inhibitors (Fluoxetine, Seratiline) are better tolerated and provide greater benefits on depressed mood and sleep disturbance than TCA's. Tramadol has been shown in several trials to reduce pain . Apart from addressing the depression and pain, it is also important to minimize fatigue by promoting a healthy sleep regimen.